Delivery of formyl peptide receptor 1 (FPR1) antagonist cyclosporin H reduces neutrophil recruitment in acid-induced lung inflammation. Delivery of formyl.

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Presentation transcript:

Delivery of formyl peptide receptor 1 (FPR1) antagonist cyclosporin H reduces neutrophil recruitment in acid-induced lung inflammation. Delivery of formyl peptide receptor 1 (FPR1) antagonist cyclosporin H reduces neutrophil recruitment in acid-induced lung inflammation. Timeline of cyclosporin H (CsH) treatment during hydrochloric acid induced acute lung injury (A). CsH attenuated bronchoalveolar lavage fluid (BALF) neutrophil numbers (B, p=0.008) and TNFα levels (C, p=0.012) (n=12–16/group). In separate experiments CsH was administered intraperitoneally solely 12 hours after acid instillation with animals culled at 24 hours (D). BALF neutrophil number (E, p=0.022) was again reduced following CsH treatment. Representative cytocentrifuge preparations shown (×400 magnification) (F). n=7/group, *p<0.05, Student's t test. David A Dorward et al. Thorax 2017;72:928-936 Copyright © BMJ Publishing Group Ltd & British Thoracic Society. All rights reserved.