Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray by Wolf-K. Hofmann, Sven de Vos, Kunihiro Tsukasaki, William.

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Presentation transcript:

Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray by Wolf-K. Hofmann, Sven de Vos, Kunihiro Tsukasaki, William Wachsman, Geraldine S. Pinkus, Jonathan W. Said, and H. Phillip Koeffler Blood Volume 98(3):787-794 August 1, 2001 ©2001 by American Society of Hematology

Distribution of gene expression in MCL samples Distribution of gene expression in MCL samples.Overview of the number of genes that were unchanged or either up- or down-regulated at least 2-, 3-, 5-, or 10-fold in 3 (░), 4 (▪), or 5 (■) of the 5 MCL samples compared to expression in HL samples. Distribution of gene expression in MCL samples.Overview of the number of genes that were unchanged or either up- or down-regulated at least 2-, 3-, 5-, or 10-fold in 3 (░), 4 (▪), or 5 (■) of the 5 MCL samples compared to expression in HL samples. We focused on genes that were more than 3-fold up- or down-regulated in at least 4 of 5 MCL samples. Wolf-K. Hofmann et al. Blood 2001;98:787-794 ©2001 by American Society of Hematology

Correlation between gene expression measured by microarray and real-time PCR for selected genes.Expression data from the oligonucleotide microarray analyses (░) were confirmed for selected genes in a larger set of clinical samples from MCL by real-time PCR ... Correlation between gene expression measured by microarray and real-time PCR for selected genes.Expression data from the oligonucleotide microarray analyses (░) were confirmed for selected genes in a larger set of clinical samples from MCL by real-time PCR (▪). All the real-time PCR experiments were done in triplicate. The variance between the triplicates was less than 5%, and the results were normalized to the expression of β-actin in each of the samples. Wolf-K. Hofmann et al. Blood 2001;98:787-794 ©2001 by American Society of Hematology

Apoptotic pathways disrupted in MCL as detected by microarray analysis and confirmed by real-time PCR.Expression of several genes acting in concert to regulate the balance between proliferation and programmed cell death are altered in MCL as compared to non... Apoptotic pathways disrupted in MCL as detected by microarray analysis and confirmed by real-time PCR.Expression of several genes acting in concert to regulate the balance between proliferation and programmed cell death are altered in MCL as compared to nonmalignant HLs. The down-regulation of FADD causes a blockade of the FAS-FADD apoptotic pathway leading to secondary changes in expression of proapoptotic genes. In addition, PDCD1 and RAIDD, which can directly induce apoptosis, are markedly down-regulated in MCL. Wolf-K. Hofmann et al. Blood 2001;98:787-794 ©2001 by American Society of Hematology