Autologous Platelet-Rich Plasma Reduces Transfusions During Ascending Aortic Arch Repair: A Prospective, Randomized, Controlled Trial Shao Feng Zhou,

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Autologous Platelet-Rich Plasma Reduces Transfusions During Ascending Aortic Arch Repair: A Prospective, Randomized, Controlled Trial Shao Feng Zhou, MD, Anthony L. Estrera, MD, Paul Loubser, MD, Craig Ignacio, MD, Sreelatha Panthayi, MD, Charles Miller, PhD, Roy Sheinbaum, MD, Hazim J. Safi, MD The Annals of Thoracic Surgery Volume 99, Issue 4, Pages 1282-1290 (April 2015) DOI: 10.1016/j.athoracsur.2014.11.007 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Whole blood is harvested from the patient and separated into the red blood cell (RBC) fraction and the autologous platelet-rich plasma (aPRP) fraction. Red blood cells may be retransfused at any time during the procedure. The aPRP fraction is reinfused after cardiopulmonary bypass is completed and anticoagulation is reversed. The Annals of Thoracic Surgery 2015 99, 1282-1290DOI: (10.1016/j.athoracsur.2014.11.007) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Perioperative hematocrit (Hct; blue, red lines and symbols) and platelet levels (green, purple lines and symbols) for the autologous platelet-rich plasma (aPRP; blue, green lines and symbols) and without aPRP (red, purple lines and symbols) groups. (Post-OP = postoperative; Pre-OP = preoperative.) The Annals of Thoracic Surgery 2015 99, 1282-1290DOI: (10.1016/j.athoracsur.2014.11.007) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Perioperative coagulation studies for the autologous platelet-rich plasma (aPRP; blue, green, light aqua lines and symbols) and without aPRP (red, purple, orange lines and symbols) groups. (INR = international normalized ratio; PT = prothrombin time; PTT = partial thromboplastin time.) The Annals of Thoracic Surgery 2015 99, 1282-1290DOI: (10.1016/j.athoracsur.2014.11.007) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions