Pheochromocytoma Producing Vasoactive Intestinal Peptide

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Pheochromocytoma Producing Vasoactive Intestinal Peptide Stephen L. Smith, MD, A.L. Jackson Slappy, MD, Thomas P. Fox, MD, James S. Scolapio, MD Mayo Clinic Proceedings Volume 77, Issue 1, Pages 97-100 (January 2002) DOI: 10.4065/77.1.97 Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Cut surface of the adrenal gland shows a 6-cm medullary tumor with central yellow-white necrosis (arrow) of an otherwise red-pink glistening homogeneous tumor, typical of a pheochromocytoma. Mayo Clinic Proceedings 2002 77, 97-100DOI: (10.4065/77.1.97) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Left, Sheets of tumor cells are divided and packaged by a thin fibrovascular stroma (arrows), creating a typical “zellballen” appearance of a paraganglioma (hematoxylineosin, original magnification x100). Right, Higher power examination reveals variably sized nuclei with some chromatin clearing, tiny nucleoli, and occasional multinucleation. Granular cytoplasm is present in all tumor cells (hematoxylineosin, original magnification x400). Mayo Clinic Proceedings 2002 77, 97-100DOI: (10.4065/77.1.97) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions