Circulating concentration of stem cell factor in serum of stimulated IVF patients Ali Salmassi, Sandy Zorn, Liselotte Mettler, Kerstin Koch, Walter Jonat,

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Presentation transcript:

Circulating concentration of stem cell factor in serum of stimulated IVF patients Ali Salmassi, Sandy Zorn, Liselotte Mettler, Kerstin Koch, Walter Jonat, Andreas G. Schmutzler Reproductive BioMedicine Online Volume 22, Issue 2, Pages 140-147 (February 2011) DOI: 10.1016/j.rbmo.2010.10.008 Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Correlation between stem cell factor (SCF) concentrations in serum and follicular fluid (FF) on the day of oocyte retrieval (n=74, r=0.76, P<0.001, regression coefficient b1=0.767, Pearson). Reproductive BioMedicine Online 2011 22, 140-147DOI: (10.1016/j.rbmo.2010.10.008) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Correlation between stem cell factor (SCF) concentrations and total injected dose of gonadotrophins in (a) serum (P<0.001, r=0.89, r2=0.797, b1=4.39) and (b) follicular fluid (FF) (P<0.001, r=0.85, r2=0.787, b1=4.54) based on the number of follicles (f). Reproductive BioMedicine Online 2011 22, 140-147DOI: (10.1016/j.rbmo.2010.10.008) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Stem cell factor (SCF) concentrations, based on the number of follicles (f) in (a) serum and (b) follicular fluid (FF) according to the response to ovarian stimulation. The differences among low, moderate and high responders were significant according to the Kruskal–Wallis test (P=0.0001). Paired comparisons according to the Mann Whitney U-test (high/moderate, high/low, moderate/low) in serum and FF were statistically significant, as seen in Table 1. Reproductive BioMedicine Online 2011 22, 140-147DOI: (10.1016/j.rbmo.2010.10.008) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Comparison of the concentration of stem cell factor (SCF) in the serum of patients throughout the ovarian cycle and gestation (n=30). ET=embryo transfer; f=follicle; FP=day of follicular puncture; HCG=human chorionic gonadotrophin; sd=stimulation days; w=week; ●=outliers; ∗=statistically significant difference. See Tables 2 and 3 for statistical analysis. Reproductive BioMedicine Online 2011 22, 140-147DOI: (10.1016/j.rbmo.2010.10.008) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions