Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency Jonathan P. Lane, MBBS, Christopher.

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Presentation transcript:

Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency Jonathan P. Lane, MBBS, Christopher J. Stewart, PhD, Stephen P. Cummings, PhD, Andrew R. Gennery, MD Journal of Allergy and Clinical Immunology Volume 138, Issue 2, Pages 622-625.e3 (August 2016) DOI: 10.1016/j.jaci.2016.02.019 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 PLS-DA showing separation of metabolite profiles by pre- or post-HSCT status. X/Y overview values for pre- and post-HSCT: R2 = 0.77, Q2 = 0.6; values >0.5 demonstrate data passes validation and are robust and reproducibly predictive of pre- and post-HSCT grouping. Journal of Allergy and Clinical Immunology 2016 138, 622-625.e3DOI: (10.1016/j.jaci.2016.02.019) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Level 2 PICRUSt (phylogenetic investigation of communities by reconstruction of unobserved states) analysis for patients A (A), B (B), and D (C). T (blue)—day of HSCT. N (green)—neutrophil engraftment. Conditioning (yellow): Treo/flu/C1H—treosulfan, fludarabine, Campath. Antibiotics (black): T—teicoplanin; M—meropenem; S—co-trimoxazole; C—ceftazidime; V—vancomycin; A—amikacin; Aug—co-amoxiclav. Clinically significant complications noted (orange). Journal of Allergy and Clinical Immunology 2016 138, 622-625.e3DOI: (10.1016/j.jaci.2016.02.019) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Level 3 PICRUSt (phylogenetic investigation of communities by reconstruction of unobserved states) analysis for bacterial cell motility expression (A-C) and membrane transport expression (D-E) for patients A, B, and D. T (blue)—day of HSCT. N (green)—day of neutrophil engraftment. Conditioning (yellow): Treo/flu/C1H—treosulfan, fludarabine, Campath. Antibiotics (black): T—teicoplanin; M—meropenem; S—co-trimoxazole; C—ceftazidime; V—vancomycin; A—amikacin; Aug—co-amoxiclav. Clinically significant complications noted (orange). Journal of Allergy and Clinical Immunology 2016 138, 622-625.e3DOI: (10.1016/j.jaci.2016.02.019) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions