Copy-number alterations in an archival breast cancer sample.

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Copy-number alterations in an archival breast cancer sample. Copy-number alterations in an archival breast cancer sample. A, sequence coverage is shown for each target in the tumor sample compared with a normal diploid sample. Exon targets from several genes with copy-number gains and losses are highlighted. B, copy-number correlation between exon capture and QPCR in sample FFPE 5. Quantitative PCR of FGFR1, CCND1, and NOTCH1 with 3 independent sets of primers was performed and average values for each gene were compared to exon capture copy-number. Nikhil Wagle et al. Cancer Discov 2012;2:82-93 ©2012 by American Association for Cancer Research