Preclinical animal models in single site cartilage defect testing: a systematic review  B.J. Ahern, J. Parvizi, R. Boston, T.P. Schaer  Osteoarthritis and Cartilage  Volume 17, Issue 6, Pages 705-713 (June 2009) DOI: 10.1016/j.joca.2008.11.008 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Mean chondral and subchondral defect volumes of species analyzed compared to human clinical defects. Subchondral bone plate is zero. Osteoarthritis and Cartilage 2009 17, 705-713DOI: (10.1016/j.joca.2008.11.008) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Chondral and subchondral components of the preclinical animal model defects as a percentage of the total defect compared to the human patient. Osteoarthritis and Cartilage 2009 17, 705-713DOI: (10.1016/j.joca.2008.11.008) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 A comparison of the cartilage volume of critical sized defects to the average reported cartilage defect volume assuming both are full thickness cartilage defects. Osteoarthritis and Cartilage 2009 17, 705-713DOI: (10.1016/j.joca.2008.11.008) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions