Repeated Heart Rate Measurement and Cardiovascular Outcomes in Left Ventricular Systolic Dysfunction Victoria Hamill, PhD, Ian Ford, PhD, Kim Fox, MD,

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Repeated Heart Rate Measurement and Cardiovascular Outcomes in Left Ventricular Systolic Dysfunction Victoria Hamill, PhD, Ian Ford, PhD, Kim Fox, MD, Michael Böhm, MD, PhD, Jeffrey S. Borer, MD, Roberto Ferrari, MD, PhD, Michel Komajda, MD, Philippe Gabriel Steg, MD, Luigi Tavazzi, MD, PhD, Michal Tendera, MD, PhD, Karl Swedberg, MD, PhD The American Journal of Medicine Volume 128, Issue 10, Pages 1102-1108.e6 (October 2015) DOI: 10.1016/j.amjmed.2015.04.042 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Results from Cox proportional hazards models for each of the cardiovascular outcomes. Results plotted are estimated HRs for an adverse outcome and 95% CIs for heart rate subgroups relative to heart rates in the interval <60 beats/min (<65 beats/min for baseline). Results are shown for (A) baseline heart rate, (B) time-updated heart rate, (C) time-updated heart rate adjusted for baseline heart rate, and (D) time-updated heart rate adjusted for the most recent previous heart rate. beats/min = beats per minute; CV = cardiovascular; HF = heart failure; MI = myocardial infarction. The American Journal of Medicine 2015 128, 1102-1108.e6DOI: (10.1016/j.amjmed.2015.04.042) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Results from Cox proportional hazards models for each of the cardiovascular outcomes. Results plotted are estimated HRs for an adverse outcome and 95% CIs for heart rate subgroups relative to heart rates in the interval <60 beats/min (<65 beats/min for baseline). Results are shown for (A) baseline heart rate, (B) time-updated heart rate, (C) time-updated heart rate adjusted for baseline heart rate, and (D) time-updated heart rate adjusted for the most recent previous heart rate. beats/min = beats per minute; CV = cardiovascular; HF = heart failure; MI = myocardial infarction. The American Journal of Medicine 2015 128, 1102-1108.e6DOI: (10.1016/j.amjmed.2015.04.042) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 Results from Cox proportional hazards models for each cardiovascular outcome. Results plotted are estimated HRs and 95% CIs for heart rate as a continuous predictor of an adverse outcome. Results are shown for a heart rate increase of 5 beats/min. Results are shown for baseline heart rate, time-updated heart rate, time-updated heart rate adjusted for baseline heart rate, and time-updated heart rate adjusted for the most recent previous heart rate. CV = cardiovascular; HF = heart failure; MI = myocardial infarction. The American Journal of Medicine 2015 128, 1102-1108.e6DOI: (10.1016/j.amjmed.2015.04.042) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure B1 Results from Cox proportional hazards models for each of the cardiovascular outcomes for patients with a baseline heart rate ≥70 beats/min. Results plotted are estimated HRs for an adverse outcome and 95% CIs for heart rate subgroups relative to heart rates in the interval <60 beats/min (<75 beats/min for baseline). Results are shown for (A) baseline heart rate, (B) time-updated heart rate, (C) time-updated heart rate adjusted for baseline heart rate, and (D) time-updated heart rate adjusted for the most previous heart rate. beats/min = beats per minute; CV = cardiovascular; HF = heart failure; MI = myocardial infarction. The American Journal of Medicine 2015 128, 1102-1108.e6DOI: (10.1016/j.amjmed.2015.04.042) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure B2 Results from Cox proportional hazards models for each of the cardiovascular outcomes for patients with a baseline heart rate ≥70 beats/min. Results plotted are estimated HRs and 95% CIs, for a heart rate as a continuous predictor of an adverse outcome. Results are shown for a heart rate increase of 5 beats/min. Results are shown for baseline heart rate, time-updated heart rate, time-updated heart rate adjusted for baseline heart rate, and time-updated heart rate adjusted for the most previous heart rate. CV = cardiovascular; HF = heart failure; MI = myocardial infarction. The American Journal of Medicine 2015 128, 1102-1108.e6DOI: (10.1016/j.amjmed.2015.04.042) Copyright © 2015 Elsevier Inc. Terms and Conditions