Volume 113, Issue 1, Pages (January 1998)

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Volume 113, Issue 1, Pages 249-251 (January 1998) Usual Interstitial Pneumonitis Responsive to Corticosteroids Following Varicella Pneumonia Joseph Keane, MD, Bernadette Gochuico, MD, John M. Kasznica, MD, Hardy Kornfeld, MD CHEST Volume 113, Issue 1, Pages 249-251 (January 1998) DOI: 10.1378/chest.113.1.249 Copyright © 1998 The American College of Chest Physicians Terms and Conditions

1 Roentgenograms of chest. a: a premorbid film with clear lung fields. b: bilateral reticulonodular infiltrates at the time of the varicella illness. c: resolution of infiltrates after treatment with acyclovir. Kyphoscoliosis also is noted. There was no mediastinal lymph node enlargement, and signs of cardiac failure were not evident. CHEST 1998 113, 249-251DOI: (10.1378/chest.113.1.249) Copyright © 1998 The American College of Chest Physicians Terms and Conditions

2 Histopathologic findings shown in wedge biopsy specimen removed from lung, a: patchy concentration of interstitial fibrosis in the center of the figure and predominantly lymphoid inflammation. Alveolar macrophages are readily seen and proliferation of type 2 pneumocytes is best recognized by the “hobnail” appearance (arrows) of the cells toward the lumen of the alveoli (Masson trichrome stain, high contrast, original ×120). b: higher power view of the biopsy specimen highlights the interstitial fibrosis. The alveolar architecture is still recognizable (reticulin stain, original ×160). c: widened interstitium showing moderated patchy lymphocytic infiltrates (hematoxylin-eosin, original ×250). CHEST 1998 113, 249-251DOI: (10.1378/chest.113.1.249) Copyright © 1998 The American College of Chest Physicians Terms and Conditions