Asthma therapy and airway remodeling

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Presentation transcript:

Asthma therapy and airway remodeling Thais Mauad, MD, PhD, Elisabeth H. Bel, MD, PhD, Peter J. Sterk, MD, PhD Journal of Allergy and Clinical Immunology Volume 120, Issue 5, Pages 997-1009 (November 2007) DOI: 10.1016/j.jaci.2007.06.031 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A and C, Normal airways. B and D, Airways from a patient with fatal asthma. Mucus plug within the airway lumen, epithelial folding and thickened ASM layer in B. Mucus plugging and increased ASM thickness in D, with spreading of the inflammation to the surrounding peribronchiolar alveoli.∗ Hematoxylin and eosin. A and B, ×25. C and D, ×100. C, Cartilage; Ep, epithelium; M, mucus. Journal of Allergy and Clinical Immunology 2007 120, 997-1009DOI: (10.1016/j.jaci.2007.06.031) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Normal bronchial mucosa. The epithelium is intact and composed of ciliated columnar cells. B, Bronchial mucosa from a patient with fatal asthma. There is epithelial damage and basement membrane thickening (arrow). The lamina propria is thickened with inflammation and numerous capillaries.∗ The ASM layer is thickened. Hematoxylin and eosin. ×200. Ep, Epithelium; SMG, submucosal glands. Journal of Allergy and Clinical Immunology 2007 120, 997-1009DOI: (10.1016/j.jaci.2007.06.031) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions