Growth Hormone Receptor

Slides:



Advertisements
Similar presentations
Topic Cell Signaling. Topic Focus on higher order vertebrates Multiple levels of cell signaling Endocrine Cells producing signaling factors.
Advertisements

MOLECULAR ENDOCRINOLOGY AND IMMUNOLOGY LECTURE 7 - Mechanism of action of growth hormone and prolactin Growth hormone: general actions; receptor; signal.
Signal Transduction Mechanisms Underlying Underlying Growth Control and Oncogenesis Ronit Sagi-Eisenberg Dept. of Cell and Developmental Biology Sackler.
SIGNALING FROM THE CELL SURFACE TO THE NUCLEUS
Structural Basis for Ligand- Receptor Recognition and Dimerization Moosa Mohammadi Dept. of Pharmacology Medical Science Building, 4th Floor, Rooms 425,
Cell Signaling I Signaling molecules and their receptors
Lecture 23 Signal Transduction 2
Signal Pathways in Eukaryotic Cells Overview. Lipid Soluble Hormones.
IGF in circulation The majority (> 75 %) exists as bound form –IGF binding proteins (IGFBPs) IGFBPs –6 proteins and several related proteins –Serum IGFBP.
Colony-Stimulating Factor Receptor (CSF-1R); c-fms.
Insulin-Like Growth Factor 1 Matthew Klinka
Books Molecular Cell Biology Lodish
Cell-cell Communications in Development
Signal Response and Amplification
Cell Communication Chapter Cell Communication: An Overview  Cells communicate with one another through Direct channels of communication Specific.
Signal Transduction I Receptors & Ligands. Signal Transduction.
Signaling Machinery The Signals The Receivers
Graves’ Disease Case: Previously Normal thyroid signaling requires circuit of signaling: hypothalamus, pituitary, thyroid Signaling between any cells requires.
Ion channels as targets for G-proteins G-protein-coupled receptors can control ion channel function directly by mechanisms that do not involve second messengers.
Chapter 15- Cell Communication Part I- General signaling strategies
Specific Defenses of the Host Part 2 (acquired or adaptive immunity)
Negative regulation of cell cycle by intracellular signals Checkpoint p53 detects DNA damage & activates p21 p21 inhibits cdk2-cyclinA Intracellular Regulation.
Transduction of Extracellular Signals Specific receptors in plasma membranes respond to external chemicals (ligands) that cannot cross the membrane: hormones,
Protein Receptors & Signal Transduction
Lecture 16 Signal Transduction Chapter 13.
Date of download: 9/17/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Schematic comparison of structural features of cell surface growth.
Page 1 What is TGF-β —Creative BioMart. Page 2 The transforming growth facor beta (TGF-β) superfamily is a large family of growth factors named after.
An Introduction to Medicinal Chemistry 3/e PROTEINS AS DRUG TARGETS:
Chapter 43 The Immune System.
Schematic comparison of structural features of cell surface growth factor receptor tyrosine kinases and membrane-associated tyrosine kinase oncogene products.
Growth factors Polypeptides in nature
Integrin signalling Vytášek 2010.
Recognition of Antigen By T cells: The TCR
Cell Signaling.
Cell Communication.
Human Health and Disease
Cell Communication Review
Cell Communication.
IgSF.
TCR RECEPTORS Main receptors -αβ(Alpha &beta) - γδ(Gamma& delta)
Expression of Human Genes
Cell Communication Chapter 9.
Sustaining Proliferative Signaling and Evading Growth Suppressors
Chap. 16 Problem 1 Cytokine receptors and RTKs both form functional dimers on binding of ligand. Ligand binding activates cytosolic kinase domains which.
TGFb –Superfamily Proteins
You have identified a novel cytoplasmic protein
Cell Signaling.
Cell Communication.
Signaling Machinery The Signals The Receivers
Bio 3411 Lecture IV. Mechanisms of Neural Development
Cell Communication.
Cell to Cell Communication via Enzyme Linked Receptors
Biology of common β receptor–signaling cytokines
Inborn Errors of Human JAKs and STATs
Integrin signalling Vytášek 2009.
Figure 2 Oestrogen receptor signalling pathways
Signal transduction: Gyrating protein kinases
Cell to Cell Communication
Cell Communication.
Cell Communication.
Cell Communication.
Volume 11, Issue 2, Pages (January 2001)
T cell receptor complex and diversity
Volume 123, Issue 6, Pages (December 2002)
Platelet-derived growth factor (PDGF) signalling pathway.
Components and outcomes of selected TNF-superfamily signalling pathways. Components and outcomes of selected TNF-superfamily signalling pathways. (Left)
SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans  Derek S Sieburth, Qun Sun,
UPR and cross-talk between apoptosis and metabolism.
Connections between insulin/insulin-like growth factor 1 signaling and metabolic pathways in tumor cells. Connections between insulin/insulin-like growth.
Cell Signaling A video screencast of this presentation can be accessed at:
Presentation transcript:

Growth Hormone Receptor Protein Structure Growth Hormone Receptor

Normal Growth Hormone Receptor Activation Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic receptor domain. Erythropoietin Ligand Binding Receptor Superfamily Members of this family interact with erythropoietin (EPO), inducing subsequent initiation of the chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast (nucleated erythrocyte) proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The protein domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.

Insulin-Like Growth Factor I

Role of hIGF-1 in Laron Syndrome Structure & Function Human insulin-like growth factors I and II (hIGF-I, hIGF-II) are potent stimulators of cell and growth processes. They display high sequence similarity to both the A and B chains of insulin but contain an additional connecting C-domain. The human insulin-like growth factor structure features peptide-bond cleavage between Ser35 and Arg36 resulting in a gap between residues 35 and 39. The equivalent region of proinsulin is involved in hormone processing. Role of hIGF-1 in Laron Syndrome The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. hIGF-1 (Human Insulin-like Growth Factor 1) mediates many of the growth-promoting effects of growth hormone. Laron Syndrome results from failure to generate hIGF-1 due to dysfunction of the growth hormone receptor. Growth Hormone levels are normal or increased in affected individuals.

Growth Hormone Receptor Gene The Growth Hormone Receptor Gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as growth hormone insensitivity syndrome (GHIS).

Case Studies

Conclusion

Refrences