Volume 63, Issue 3, Pages (March 2003)

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Volume 63, Issue 3, Pages 899-907 (March 2003) IL-1β, TNF-α, TGF-β, and bFGF expression in bone biopsies before and after parathyroidectomy Francisco R. Lello Santos, Rosa M.A. Moysés, Fábio L.M. Montenegro, Vanda Jorgetti, Irene L. Noronha Kidney International Volume 63, Issue 3, Pages 899-907 (March 2003) DOI: 10.1046/j.1523-1755.2003.00835.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Immunohistochemistry for cytokines and growth factors in bone biopsies. Positive staining appears as brown color (×100). (A) Interleukin-1β (IL-1β) expression in medullar fibrosis and resorption areas in a patient with severe hyperparathyroidism (HPT). (B) After parathyroidectomy (PTX), only a discrete positivity for IL-1β is observed. (C) Tumor necrosis factor-α (TNF-α) expression in resorptive lacunae before PTX. (D) Almost no TNF-α staining after PTX. (E) Intense immunostaining for transforming growth factor-β (TGF-β) in the fibrous area adjacent to the cellular tissue. (F) After PTX, a very weak immunostaining for TGF-β is observed. (G) basic fibroblast growth factor (bFGF) in the fibrotic marrow replacement of the normal bone marrow tissue before PTX. (H) Weak staining for bFGF in osteoid surface after PTX. Kidney International 2003 63, 899-907DOI: (10.1046/j.1523-1755.2003.00835.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Quantitative expression of interleukin-1β (IL-1β) (A), tumor necrosis factor-α (TNF-α) (B), transforming growth factor-β (TGF-β) (C), andbasic fibroblast growth factor (bFGF) (D) (%) of cytokines and growth factors in bone biopsies before and 1 year after parathyroidectomy (PTX). *P < 0.001 vs. before PTX; #P < 0.05 vs. after PTX. Kidney International 2003 63, 899-907DOI: (10.1046/j.1523-1755.2003.00835.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between interleukin-1β (IL-1β) (A), tumor necrosis factor-α (TNF-α) (B), transforming growth factor-β (TGF-β) (C), andbasic fibroblast growth factor (bFGF) (D) expression in bone biopsies with intact parathyroid (iPTH) levels before (○) and one year after (•) parathyroidectomy (PTX). Kidney International 2003 63, 899-907DOI: (10.1046/j.1523-1755.2003.00835.x) Copyright © 2003 International Society of Nephrology Terms and Conditions