Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: A canine model experiment Masaki Kajimoto, MD, Takatsugu.

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Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: A canine model experiment Masaki Kajimoto, MD, Takatsugu Shimono, MD, Koji Hirano, MD, Yoichiro Miyake, MD, Noriyuki Kato, MD, Kyoko Imanaka-Yoshida, MD, Hideto Shimpo, MD, Keiichi Miyamoto, PhD Journal of Vascular Surgery Volume 48, Issue 5, Pages 1306-1314 (November 2008) DOI: 10.1016/j.jvs.2008.05.060 Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 1 Canine aneurysm model with endoleaks. A, The S/G with a 2mm hole in six places for creating endoleaks. B, Descending aortic aneurysms are surgically created with a jugular vein patch. C, Angiography around the time when the S/G was inserted. Endoleaks are present in the angiographic late phase. Journal of Vascular Surgery 2008 48, 1306-1314DOI: (10.1016/j.jvs.2008.05.060) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 2 Reaction of bFGF for normal aortic intima. A, Macroscopic findings, the proximal side of the bFGF-S/Gs is completely covered with intima (b), while the proximal side of the C-S/Gs is not covered (a). Histological findings of hematoxylin and eosin stain, the intimal outgrowth beyond the boundaries of the graft are present in the bFGF-S/G group (d), however are not present in the C-S/G group (c). Cross-section specimens of canine aorta at two weeks after the endovascular procedure show intimal hyperplasia (asterisks) in the bFGF-S/Gs compared with the C-S/Gs (e, C-S/Gs; f, bFGF-S/Gs). †e-PTFE graft. ‡aortic wall. B, The width ratio of neointima in ePTFE in the cross-section specimens. Proliferation of intima in the bFGF-S/G group is significantly higher. §P < .01. Journal of Vascular Surgery 2008 48, 1306-1314DOI: (10.1016/j.jvs.2008.05.060) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 3 Evaluation of organization in the aneurysmal cavity. A, The cross-section specimens in the maximum transverse diameter are analyzed macroscopically and microscopically at 2 weeks after S/G insertion. The majority of the aneurysmal cavity in the C-S/G group is composed of red blood cells (a and c). The aneurysmal cavity in the bFGF-S/G group is partly filled with organizing tissues with cells and collagen fibers (b and d). B, Average percentages of organized areas in the aneurysmal cavity in each group at two weeks after S/G insertion. Organization in the bFGF-S/G group is more progressed than in the C-S/G group. C, Cross-section specimens at four weeks after S/G insertion. The aneurysmal cavity in the bFGF-S/G group is almost completely filled with cellular components (b). In the C-S/G group, the aneurysmal cavity is composed of many red blood cells and a little fibrosis (a). A-a through d, C-a, and C-b, Masson's trichrome stain; *P < .01; bars = 100 μm. Journal of Vascular Surgery 2008 48, 1306-1314DOI: (10.1016/j.jvs.2008.05.060) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 4 Histological findings of Sirius red (A) and α-SMA stain (B) in the aneurysmal cavity at two weeks after S/G insertion. A, Collagen fiber stained with red is present in the bFGF-S/G group (b), while collagen fiber is not present in the C-S/G group (a). B, α-SMA-positive cells stained with brown are present in the bFGF-S/G group (b), while α-SMA-positive cells are not present in the C-S/G group (a). #1: aneurysmal wall; #2: aneurysmal cavity; #3: ePTFE graft; bars = 100μm. Journal of Vascular Surgery 2008 48, 1306-1314DOI: (10.1016/j.jvs.2008.05.060) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions