Mutations of p53 in barrett's esophagus and barrett's cancer: A prospective study of ninety-eight cases Paul M. Schneider, MD (by invitation)a, Alan.

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Presentation transcript:

Mutations of p53 in barrett's esophagus and barrett's cancer: A prospective study of ninety-eight cases Paul M. Schneider, MD (by invitation)a, Alan G. Casson, FRCSC (by invitation)c*, Bernard Levin, MD (by invitation)f, Harinder S. Garewal, MD (by invitation)e, Arnulf H. Hoelscher, MD (by invitation)a, Karen Becker, MD (by invitation)b, Hans-Joachim Dittler, MD (by invitation)a, Karen R. Cleary, MD (by invitation)g, Michael Troster, MD (by invitation)d, J. Ruediger Siewert, MD (by invitation)a, Jack A. Roth, MDh The Journal of Thoracic and Cardiovascular Surgery Volume 111, Issue 2, Pages 323-333 (February 1996) DOI: 10.1016/S0022-5223(96)70441-5 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Left panel, PCR SSCP analysis of exon 8 in a patient with Barrett's cancer (patient 28). Specimens were analyzed from the tumor (T1), two separate foci of Barrett's epithelium with LGD (B1) and NOD (B2), and histologically normal esophageal squamous epithelium (E). An electrophoretic mobility shift (aberrant bands) is clearly detected in T1 (arrows). Right panel, DNA sequencing of tumor (T) and epithelium (E) showed a guanine to adenine transition mutation (arrow) in codon (CGG → CAG) that resulted in an amino acid change (glycine → arginine). The Journal of Thoracic and Cardiovascular Surgery 1996 111, 323-333DOI: (10.1016/S0022-5223(96)70441-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Left panel, PCR SSCP analysis of exon 8 in a patient with Barrett's cancer (patient 28). Specimens were analyzed from the tumor (T1), two separate foci of Barrett's epithelium with LGD (B1) and NOD (B2), and histologically normal esophageal squamous epithelium (E). An electrophoretic mobility shift (aberrant bands) is clearly detected in T1 (arrows). Right panel, DNA sequencing of tumor (T) and epithelium (E) showed a guanine to adenine transition mutation (arrow) in codon (CGG → CAG) that resulted in an amino acid change (glycine → arginine). The Journal of Thoracic and Cardiovascular Surgery 1996 111, 323-333DOI: (10.1016/S0022-5223(96)70441-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Left panel, PCR SSCP analysis of exon 8 in a patient with Barrett's cancer (patient 28). Specimens were analyzed from the tumor (T1), two separate foci of Barrett's epithelium with LGD (B1) and NOD (B2), and histologically normal esophageal squamous epithelium (E). An electrophoretic mobility shift (aberrant bands) is clearly detected in T1 (arrows). Right panel, DNA sequencing of tumor (T) and epithelium (E) showed a guanine to adenine transition mutation (arrow) in codon (CGG → CAG) that resulted in an amino acid change (glycine → arginine). The Journal of Thoracic and Cardiovascular Surgery 1996 111, 323-333DOI: (10.1016/S0022-5223(96)70441-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Left panel, PCR SSCP analysis of exon 7 in a patient with Barrett's cancer (patient 2). Specimens were analyzed from the tumor (T), Barrett's epithelium with no evidence of dysplasia (B), and histologically normal squamous esophageal epithelium (E). An electrophoretic mobility shift was detected in B (arrow). Right panel, DNA sequencing of B and E revealed a one base pair guanine deletion (arrow) in codon 237 (GTG → TG), which resulted in a frameshift. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 323-333DOI: (10.1016/S0022-5223(96)70441-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Left panel, PCR SSCP analysis of exon 7 in a patient with Barrett's cancer (patient 2). Specimens were analyzed from the tumor (T), Barrett's epithelium with no evidence of dysplasia (B), and histologically normal squamous esophageal epithelium (E). An electrophoretic mobility shift was detected in B (arrow). Right panel, DNA sequencing of B and E revealed a one base pair guanine deletion (arrow) in codon 237 (GTG → TG), which resulted in a frameshift. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 323-333DOI: (10.1016/S0022-5223(96)70441-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Left panel, PCR SSCP analysis of exon 7 in a patient with Barrett's cancer (patient 2). Specimens were analyzed from the tumor (T), Barrett's epithelium with no evidence of dysplasia (B), and histologically normal squamous esophageal epithelium (E). An electrophoretic mobility shift was detected in B (arrow). Right panel, DNA sequencing of B and E revealed a one base pair guanine deletion (arrow) in codon 237 (GTG → TG), which resulted in a frameshift. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 323-333DOI: (10.1016/S0022-5223(96)70441-5) Copyright © 1996 Mosby, Inc. Terms and Conditions