Making sense of the sensor: Mysteries of the macula densa

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Making sense of the sensor: Mysteries of the macula densa R.C. Blantz Kidney International Volume 70, Issue 5, Pages 828-830 (September 2006) DOI: 10.1038/sj.ki.5001739 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Proposed effects of increased macula densa flow rate and corresponding sodium chloride (NaCl) luminal concentration on macula densa cell volume. Under isosmotic conditions (upper panel), increased NaCl concentration in the lumen is associated with significant cell swelling, presumably via water entry from the basolateral aspect of the macula densa (MD) cell. With increases in both luminal osmolality and NaCl, the MD cell will decrease in volume, primarily as a result of water removal across the apical membrane. The exact physiologic effects of these changes in cell volume on the TGF signal have not been defined. Kidney International 2006 70, 828-830DOI: (10.1038/sj.ki.5001739) Copyright © 2006 International Society of Nephrology Terms and Conditions