Development In time In space.

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Presentation transcript:

Development In time In space

End result... Too complicated

End result... much simpler Bacillus sporulation Anabaena heterocysts Myxobacteria fruiting Caulobacter cell cycle

Bacillus subtilis Temporally regulated differentiation Start Restart Pause

Caulobacter crescentus Cell cycle-regulated differentiation

Anabaena Spatially regulated differentiation Time after nitrogen removal 0 h 3 h 6 h 9 h 12 h

Myxococcus xanthus Socially regulated differentiation Feast Famine

Route to altered states in bacteria Bacillus, Anabaena, Myxococcus Starvation Permissive conditions Initiation Altered State Signal transduction pH, Fe,... Pathogens

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