A, structure drawing of LY

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A, structure drawing of LY345899. A, structure drawing of LY345899. B, ribbon diagram representation of DC301 (MTHFD1; 1DIB.pdb) chain A of the dimer colored by secondary structure showing relative location of cofactor NADP (green colored spheres) to inhibitor LY34 (LY345899; CPK colored spheres). Key interacting protein residues are depicted in ball-stick and labeled. C, human MTHFD2 (1ZN4.pdb) with NAD cofactor (green spheres) and phosphate (Pi). The key residues are depicted in ball-stick. D, homology model of the human MTHFD2L enzyme with NADP cofactor (spheres with CPK coloring) bound and key residues depicted as ball-stick. Illustrations were prepared using the VMD molecular graphics software package (27). Philip M. Tedeschi et al. Mol Cancer Res 2015;13:1361-1366 ©2015 by American Association for Cancer Research