Phylogenetic tree of the human class Frizzled receptors FZD1–10 and SMO created with the ClustalW2 software (ver. 2.0.12; http://www.ebi.ac.uk/Tools/clustalw2/index.html)

Slides:

Advertisements

Similar presentations

Phylogenetic Analysis Dayong Guo. Introduction Phylogenetics is the study of evolutionary relatedness among various species, populations, or among a set.

Advertisements

Genomic Organization and Evolutionary Conservation of Plant D-Type Cyclins by Margit Menges, Giulio Pavesi, Piero Morandini, Laszlo Bögre, and James A.H.

BioMapper Bioinformatics Workflow Tool Cognitive Walkthrough 1 st November 2010.

Multiplication table. x

Unrooted phylogenetic tree showing the relationship between the human SLC2A gene family for all 14 members created using PHYLIP 3.6 softwareDistance between.

TNFR1 and TNFR2 are expressed on native human ASM but activation of TNFR1 mediates ICAM-1 expression in human ASM cells. TNFR1 and TNFR2 are expressed.

Early and late D2 dopamine receptor signaling during slow synaptic transmission. Early and late D2 dopamine receptor signaling during slow synaptic transmission.

Parallels in antimicrobial peptide mechanisms of action and resistance

Comparison of the model incorporating daily dose to that incorporating Cmax. Comparison of the model incorporating daily dose to that incorporating Cmax.

Evaluation of models incorporating the base covariates.

The context-sensitive half-times for commonly used intravenous anesthetic drugs. [Reproduced from Reves JG, Glass PSA, Lubarsky DA, McEvoy MD, and Martinez-Ruiz.

Figure 2 Circadian and ultradian fluctuations in corticosterone

Formation and metabolism of DOPAL and DOPEGAL

Retroviral vector propagation in helper cells and structure of a prototypical vector. Retroviral vector propagation in helper cells and structure of a.

Mean (± S.E.) change from baseline in the 6-min walk distance for bosentan (n = 21) and placebo (n = 11) groups. Mean (± S.E.) change from baseline in.

Mechanism of stabilization of the closed conformation of the umami receptor VFTM by IMP (green). Mechanism of stabilization of the closed conformation.

Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM.

Structure of solid lipid nanoparticles (SLNs).

Piotr Masiakowski, George D. Yancopoulos

Alterations in PUFA metabolism and flux through the P450/sEH pathway related to hypoxia and activation of the renin-angiotensin system. Alterations in.

The three primary ADC components that determine which cells are targeted (antibody), how the drug is released (linker/trigger), and the mechanism of action.

Dots 5 × TABLES MULTIPLICATION.

Dots 5 × TABLES MULTIPLICATION.

Dots 2 × TABLES MULTIPLICATION.

T-type calcium channel regulators.

5 × 7 = × 7 = 70 9 × 7 = CONNECTIONS IN 7 × TABLE

5 × 8 = 40 4 × 8 = 32 9 × 8 = CONNECTIONS IN 8 × TABLE

Piotr Masiakowski, George D. Yancopoulos

Dots 3 × TABLES MULTIPLICATION.

Mechanisms of H2S release from S-aroylthiooximes (SATOs).

Dots 6 × TABLES MULTIPLICATION.

4 × 6 = 24 8 × 6 = 48 7 × 6 = CONNECTIONS IN 6 × TABLE

5 × 6 = 30 2 × 6 = 12 7 × 6 = CONNECTIONS IN 6 × TABLE

Cytotoxic activities of polymer micelles containing CFZ in H460 (A) and select micelle formulations in RPMI-8226 (B) cell lines. Cytotoxic activities of.

Cytotoxic effects of PM1 and PM2 empty particle controls and coincubation of CFZ with empty particles tested in H460 (A) and RPMI-8226 (B) cells. Cytotoxic.

Geometric mean concentration-time profiles of (A) racemic BUP, R-BUP, and S-BUP; (B) racemic OHBUP, RR-OHBUP, and SS-OHBUP; (C) racemic ERY, SR-ERYHBUP,

The additive model assumes unspecific effects of equal size in both the placebo and drug arm or groups of studies or experiments. The additive model assumes.

Multiple sequence alignment & Phylogenetics Analysis

Dots 2 × TABLES MULTIPLICATION.

Phylogenetic analysis of replication proteins expressed by bifidobacterial plasmids. Phylogenetic analysis of replication proteins expressed by bifidobacterial.

Dots 4 × TABLES MULTIPLICATION.

Phylogenetic analysis of PurR from low-GC Gram-positive bacteria.

Selected TRPV1 agonists.

10 × 8 = 80 5 × 8 = 40 6 × 8 = CONNECTIONS IN 8 × TABLE MULTIPLICATION.

Phylogenetic trees of the closest eukaryotic homologs of clones AY and AY Phylogenetic trees of the closest eukaryotic homologs of clones.

3 × 12 = 36 6 × 12 = 72 7 × 12 = CONNECTIONS IN 12 × TABLE

x/÷ Numbers Year 3-4 – Multiply and divide a multiple of 10

(A) Illustration depicting two types of pharmacokinetic instability of an ADC. Conjugating an antibody with drug can accelerate its clearance (green versus.

5 × 12 = × 12 = × 12 = CONNECTIONS IN 12 × TABLE MULTIPLICATION.

Effects of gemfibrozil on the exposure (area under the plasma drug concentration-time curve) to different CYP2C8 substrate drugs. Effects of gemfibrozil.

Schematic illustration of the interaction between CYP2C8 and its glucuronide substrates. Schematic illustration of the interaction between CYP2C8 and its.

Results of thermogravimetric measurements of peptide ghrelin antagonist (GhA) and loaded into PSi microparticles. Results of thermogravimetric measurements.

Stereoimage of three independent docking simulations of the interaction between clopidogrel acyl 1-β-d-glucuronide and the active site of CYP2C8. Stereoimage.

5 × 9 = 45 6 × 9 = 54 7 × 9 = CONNECTIONS IN 9 × TABLE

Damage-associated molecular pattern (DAMP)-induced activation of Toll-like receptors (TLRs). Damage-associated molecular pattern (DAMP)-induced activation.

CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours.

CBD and other phytocannabinoids are not cytotoxic in HaCaT cells.

The CYP2C8 gene is located to the CYP2C gene cluster on chromosome 10.

3 × 7 = 21 6 × 7 = 42 7 × 7 = CONNECTIONS IN 7 × TABLE

Dots 3 × TABLES MULTIPLICATION.

AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels.

Involvement of cys298 in the interaction of PGA1 with AKR1B1.

Activation and desensitization of the α7 nAChRs.

Role of CETP in plasma cholesterol transport.

The effect of a change in the expression level of the receptor and the binding affinity on the subcutaneous bioavailability of mAbs. The effect of a change.

Neighbor joining tree showing relationships between the human cannabinoid CB1 and CB2 receptors and other human rhodopsin α-group type G protein-coupled.

Signaling pathways of galanin receptors.

Phylogenetic tree analysis of the Xenopus type III IFNs (A) with other known IFNs and the putative receptors (B) with relevant receptor families. Phylogenetic.

Allometric relationship between the lymph flow in the thoracic duct and species body weight. Allometric relationship between the lymph flow in the thoracic.

Toll-like receptors, adapter proteins, and signaling molecules.

Presentation transcript:

Phylogenetic tree of the human class Frizzled receptors FZD1–10 and SMO created with the ClustalW2 software (ver. 2.0.12; http://www.ebi.ac.uk/Tools/clustalw2/index.html) using multiple sequence alignment of FZD1–10 and SMO as shown in the Supplemental material. Phylogenetic tree of the human class Frizzled receptors FZD1–10 and SMO created with the ClustalW2 software (ver. 2.0.12; http://www.ebi.ac.uk/Tools/clustalw2/index.html) using multiple sequence alignment of FZD1–10 and SMO as shown in the Supplemental material. Default settings were used. Output format: phylip. Tree type: dist UniProtKB/Swiss-Prot accession numbers used for aligment; see Table 2. Gunnar Schulte Pharmacol Rev 2010;62:632-667 Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics