生化重點整理 生科2A 第17組 毛儒毅 0993B007 梁育銓 0993B036

心智圖 GTP Rx 5: Succinyl-CoA Synthetase Succinyl-CoA Synthetase FAD Rx6: Succinate Dehydrogenase Oxaloacetate Regenerated electron Rx 7:Fumarase atalyzes form L-Malate H2O NAD+ Rx8: Malate Dehydrogenase Oxidizing Malate to Oxaloacetate part 2. TCA cycle 2 G=+30 How Is the TCA Cycle Regulated?

Rx 5: Succinyl-CoA Synthetase

Rx6: Succinate Dehydrogenase Is FAD-Dependent This enzyme is actually part of the electron transport pathway in the inner mitochondrial membrane

Rx 7: Fumarase Catalyzes the Trans-Hydration of Fumarate to Form L-Malate Hydration across the double bond

Rx8: Malate Dehydrogenase Completes the Cycle by Oxidizing Malate to Oxaloacetate An NAD+-dependent oxidation Go' of +30 kJ/mol

How Is the TCA Cycle Regulated? Citrate synthase - ATP, NADH and succinyl- CoA inhibit Isocitrate dehydrogenase - ATP inhibits, ADP and NAD+ activate Ketoglutarate dehydrogenase - NADH and succinyl-CoA inhibit, AMP activates Also note pyruvate dehydrogenase: ATP, NADH, acetyl-CoA inhibit, NAD+, CoA activate

The citrate synthase synthase reaction initiates the TCA cycle

Pyruvate regulation