Volume 146, Issue 7, Pages e3 (June 2014)

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Volume 146, Issue 7, Pages 1691-1700.e3 (June 2014) Development of Hong Kong Liver Cancer Staging System With Treatment Stratification for Patients With Hepatocellular Carcinoma Thomas Yau, Vikki Y.F. Tang, Tzy-Jyun Yao, Sheung-Tat Fan, Chung-Mau Lo, Ronnie T.P. Poon Gastroenterology Volume 146, Issue 7, Pages 1691-1700.e3 (June 2014) DOI: 10.1053/j.gastro.2014.02.032 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Kaplan–Meier estimated overall survival curves of the HKLC staging system in the test set. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 The HKLC prognostic classification scheme. EVM, extrahepatic vascular invasion/metastasis. Early tumor: ≤5 cm, ≤3 tumor nodules and no intrahepatic venous invasion; Intermediate tumor: 1) ≤5 cm, either >3 tumor nodules or with intrahepatic venous invasion, or 2) >5 cm, ≤3 tumor nodules and no intrahepatic venous invasion; and Locally-advanced tumor: 1) ≤5 cm, >3 tumor nodules and with intrahepatic venous invasion, or 2) >5 cm, >3 tumor nodules or/and with intrahepatic venous invasion, or 3) diffuse tumor. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Hypothetical Kaplan–Meier estimated overall survival curves of the HKLC scheme and the BCLC scheme based on the test set. The survival data of patients not treated as recommended were replaced by random sampling from those of patients in the test set, with the same BCLC/HKLC dual classification receiving the recommended treatments. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Kaplan–Meier estimated overall survival curves of the BCLC staging system in the test set. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 Survival comparison between patients receiving different treatments according to the BCLC scheme (BCLC-B) and the HKLC scheme (HKLC-II) in the test set. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 3 Survival comparison between patients receiving different treatments according to the BCLC scheme (BCLC-C) and the HKLC scheme (HKLC-II) in the test set. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 4 Survival comparison between patients receiving different treatments according to the BCLC scheme (BCLC-C) and the HKLC scheme (HKLC-III) in the test set. Gastroenterology 2014 146, 1691-1700.e3DOI: (10.1053/j.gastro.2014.02.032) Copyright © 2014 AGA Institute Terms and Conditions