Alfons S. K. de Hooge, Ph. D. , Fons A. J. van de Loo, Ph. D

Slides:

Advertisements

Similar presentations

Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability S.H. Chang, T. Yasui, S.

Advertisements

Osteoarthritis cartilage histopathology: grading and staging

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

J. K. Meckes, B. Caramés, M. Olmer, W. B. Kiosses, S. P. Grogan, M. K

Extraction of anatomical landmarks and axis for 3D coordinate system construction of femur and tibia bone models X. Cui, H. Kim, S. Li, K.-S. Kwack,

T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis T. Weng, Y. Xie, L. Yi, J. Huang,

Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT T.M. Piscaer, M. Sandker, O.P. van der.

The relationships between bone mineral density in the spine, hip, distal femur and proximal tibia and medial minimum joint space width in the knees of.

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

Establishment of a rabbit model to study the influence of advanced glycation end products accumulation on osteoarthritis and the protective effect of.

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage.

Y. H. Sniekers, G. J. V. M. van Osch, A. G. H. Ederveen, J. Inzunza, J

Osteoarthritis pain mechanisms: basic studies in animal models

M. H. van den Bosch, A. B. Blom, V. Kram, A. Maeda, S. Sikka, Y

Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect.

High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis W. de Munter, M.H.

Angiogenesis in two animal models of osteoarthritis

Osteoarthritis as a disease of mechanics

Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1– Ddr2–Mmp-13 degradative pathway: a new model of osteoarthritis D.W.

Cartilage damage pattern in relation to subchondral plate thickness in a collagenase- induced model of osteoarthritis S.M. Botter, M.Sc., G.J.V.M. van.

The short-term therapeutic effect of recombinant human bone morphogenetic protein-2 on collagenase-induced lumbar facet joint osteoarthritis in rats

Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight I.G. Otterness, Ph.D., F. Eckstein, M.D.

The responsiveness of three-dimensional knee accelerations used as an estimation of knee instability and loading transmission during gait in osteoarthritis.

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1- CreERT2 transgenic mice M. Zhu, M.D., Ph.D., M. Chen, Ph.D., A.C. Lichtler,

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma B. Poulet, T.A.T. Westerhof, R.W. Hamilton,

Knee cartilage thickness measurements using MRI: a 4½-month longitudinal study in the meniscectomized guinea pig model of OA R. Bolbos, M.Sc., H. Benoit-Cattin,

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone K. Takebe, M.F. Rai, E.J. Schmidt,

Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability S.H. Chang, T. Yasui, S.

The course of ultrasonographic abnormalities in knee osteoarthritis: 1 year follow up K. Bevers, J.W.J. Bijlsma, J.E. Vriezekolk, C.H.M. van den Ende,

Osteoarthritis pain mechanisms: basic studies in animal models

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1- CreERT2 transgenic mice M. Zhu, M.D., Ph.D., M. Chen, Ph.D., A.C. Lichtler,

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis S.C.M. van Dalen, A.B. Blom, A.W.

P.C. Pastoureau, E.B. Hunziker, J.-P. Pelletier

Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits Dr. C.M. Robertson,

M. A. McNulty, R. F. Loeser, C. Davey, M. F. Callahan, C. M

Time to be positive about negative data?

Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT T.M. Piscaer, M. Sandker, O.P. van der.

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

Osteoarthritis cartilage histopathology: grading and staging

The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study G. Tardif, Ph.D., J.-P. Pelletier,

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

N.D. Miljkovic, M.D., Ph.D., G.M. Cooper, Ph.D., K.G. Marra, Ph.D.

Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFβ2 and FGF2 Y.M. Jenniskens, M.Sc., W. Koevoet, B.Sc., A.C.W. de.

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis S. Thysen, F.P. Luyten, R.J. Lories Osteoarthritis.

Osteoarthritis development in novel experimental mouse models induced by knee joint instability S. Kamekura, M.D., K. Hoshi, M.D., Ph.D., T. Shimoaka,

R. J. U. Lories, M. D. , Ph. D. , J. Peeters, B. Sc. , K. Szlufcik, Ph

Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced.

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis M. Blagojevic, C. Jinks, A. Jeffery, K.P.

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis M. Abdin-Mohamed, M.B.B.S., M.R.C.P.,

C. E. Berger, M. D. , A. Kröner, M. D. , K. H. Kristen, M. D. , M

Subchondral Bone Plate Sclerosis during Late Osteoarthritis is Mediated by Loading- induced Decrease in Sclerostin Amount X. Ma, H. Jia, W. Tong, Z. Yang,

Osteoarthritis and Cartilage

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (Fabp-4) alleviates osteoarthritis induced by a very high fat diet in mouse

Arjen B. Blom, Ph. D. , Peter L. E. M. van Lent, Ph. D. , Astrid E. M

Osteoarthritis severity is sex dependent in a surgical mouse model

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression D.F.G. Remst,

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

Gene expression analysis of OA synovium reveals elevation of TGF-ß responsive genes in OA-related fibrosis D.F. Remst, A.B. Blom, E.N. Blaney Davidson,

A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia D. Dore, BBiotech.(Hons.), C. Ding, M.D., G.

Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and.

Developmental failure of the intra-articular ligaments in mice with absence of growth differentiation factor 5 M. Harada, M.D., M. Takahara, M.D., Ph.D.,

A comparison of intra-articular hyaluronan injection accuracy rates between three approaches based on radiographic severity of knee osteoarthritis Y.

M. Nagao, C.W. Cheong, B.R. Olsen Osteoarthritis and Cartilage

I. G. Otterness, Ph. D. , M. -P. H. Le Graverand, M. D. , Ph. D. , F

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

Osteoarthritis year 2012 in review: biology

G. Blumenkrantz, B. S. , R. Stahl, M. D. , J. Carballido-Gamio, Ph. D

Upregulation of Atrogin-1/FBXO32 is not necessary for cartilage destruction in mouse models of osteoarthritis H.-E. Kim, J. Rhee, S. Park, J. Yang, J.-S.

Presentation transcript:

Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging Alfons S.K. de Hooge, Ph.D., Fons A.J. van de Loo, Ph.D., Miranda B. Bennink, B.Sc., Onno J. Arntz, B.Sc., Pieter de Hooge, M.D., Ph.D., Wim B. van den Berg, Ph.D. Osteoarthritis and Cartilage Volume 13, Issue 1, Pages 66-73 (January 2005) DOI: 10.1016/j.joca.2004.09.011 Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Spontaneous OA in old wt and IL-6−/− mice. wt (A, 23 months) and IL-6−/− (B, 22 months) female mice with PG deposition in the collateral ligament (arrow in A and B) but without cartilage erosion. Mild surface erosion (arrow) in the tibial cartilage of an old wt male (C, 20 months). Severe OA as seen in an old IL-6−/− male (D, 19 months). Severe cartilage erosion occurs in both femur and tibia. Bone sclerosis is seen under the affected cartilage. Bone apposition (arrows) and PG deposition occur in the collateral ligament. The normal ligament structure as seen in the wt male (E) and bone formation in the ligament of the IL-6−/− male (F) are shown in more detail. F=femur, L=ligament, T=tibia. Safranin-O staining. Original magnification: A–D 50×, E and F 500×. Osteoarthritis and Cartilage 2005 13, 66-73DOI: (10.1016/j.joca.2004.09.011) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Collagenase-induced OA in wt and IL-6−/− male mice. Severe OA at day 42 after the first collagenase injection in both wt (A) and IL-6−/− (B) male mice. Complete cartilage erosion is seen at the femur. Osteophytes are formed at the tibia and femur. PG deposition is seen in the collateral ligament. F=femur, L=ligament, T=tibia, O=osteophyte, M=meniscus. Safranin-O staining. Original magnification: 50×. Osteoarthritis and Cartilage 2005 13, 66-73DOI: (10.1016/j.joca.2004.09.011) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions