Biology of Blood and Marrow Transplantation

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Presentation transcript:

Biology of Blood and Marrow Transplantation Test Dose Pharmacokinetics to Predict Melphalan Dosing in Children Undergoing Hematopoietic Stem Cell Transplant (HSCT) with Organ Impairment☆  Sharat Chandra, Tsuyoshi Fukuda, Junfang Zhao, Kana Mizuno, Ashley Teusink-Cross, Stella M. Davies, Rebecca A. Marsh, M. Christa Krupski, Kenneth Setchell, Alexander Vinks, Parinda A. Mehta  Biology of Blood and Marrow Transplantation  Volume 23, Issue 3, (March 2017) DOI: 10.1016/j.bbmt.2016.12.451 Copyright © 2016 Terms and Conditions

Figure 1 Melphalan pharmacokinetic profiles for test dose and full dose. Biology of Blood and Marrow Transplantation 2017 23, DOI: (10.1016/j.bbmt.2016.12.451) Copyright © 2016 Terms and Conditions

Figure 2 (A) Full dose AUC distribution. (B) Comparison of melphalan clearance between test dose (CLtest) and full dose (CLfull). Biology of Blood and Marrow Transplantation 2017 23, DOI: (10.1016/j.bbmt.2016.12.451) Copyright © 2016 Terms and Conditions

Figure 3 Melphalan pharmacokinetic profiles in two patients who received adjusted full dose melphalan based on test dose pharmacokinetics. Biology of Blood and Marrow Transplantation 2017 23, DOI: (10.1016/j.bbmt.2016.12.451) Copyright © 2016 Terms and Conditions

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