Ciprofloxacin Pharmacokinetics in Critically Ill Patients Receiving Concomitant Continuous Venovenous Hemodialysis Matthew S. Shotwell, PhD, Phillip.

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Presentation transcript:

Ciprofloxacin Pharmacokinetics in Critically Ill Patients Receiving Concomitant Continuous Venovenous Hemodialysis Matthew S. Shotwell, PhD, Phillip N. Madonia, MD, Michael J. Connor, MD, Milen Amde, MD, Charbel Salem, MD, Olufemi A. Aduroja, MD, Seth R. Bauer, PharmD, Joseph J. Groszek, BS, William H. Fissell, MD American Journal of Kidney Diseases Volume 66, Issue 1, Pages 173-175 (July 2015) DOI: 10.1053/j.ajkd.2015.03.001 Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Ciprofloxacin serum concentration as a function of CRRT ciprofloxacin clearance. Filled circles, individual data points; line, linear regression estimate (P=0.02); grey area, 95% confidence region for regression line. CRRT ciprofloxacin clearance may exceed effluent flow rate, which is a consequence of the single-compartment model, which amalgamates intercompartmental and elimination clearances into a single value. American Journal of Kidney Diseases 2015 66, 173-175DOI: (10.1053/j.ajkd.2015.03.001) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions