Sirolimus-Associated Diffuse Alveolar Hemorrhage

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Sirolimus-Associated Diffuse Alveolar Hemorrhage Nicholas E. Vlahakis, MD, Otis B. Rickman, DO, Timothy Morgenthaler, MD  Mayo Clinic Proceedings  Volume 79, Issue 4, Pages 541-545 (April 2004) DOI: 10.4065/79.4.541 Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 A, Posteroanterior chest radiograph at presentation shows bilateral peripheral pulmonary infiltrates. B, Chest radiograph obtained before the patient's illness shows normal findings. Mayo Clinic Proceedings 2004 79, 541-545DOI: (10.4065/79.4.541) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Computed tomography of the chest using 5-mm slices without intravenous contrast medium shows a predominantly peripheral, bilateral ground-glass alveolar infiltrate. Mayo Clinic Proceedings 2004 79, 541-545DOI: (10.4065/79.4.541) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Follow-up computed tomography 4 months after sirolimus was permanently discontinued reveals no evidence of the bilateral ground-glass infiltrates seen on the image obtained previously (Figure 2). Mayo Clinic Proceedings 2004 79, 541-545DOI: (10.4065/79.4.541) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions