Coagulation and fibrinolytic activities in 2 siblings with β2-glycoprotein I deficiency by Rie Takeuchi, Tatsuya Atsumi, Masahiro Ieko, Hiroyuki Takeya,

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Presentation transcript:

Coagulation and fibrinolytic activities in 2 siblings with β2-glycoprotein I deficiency by Rie Takeuchi, Tatsuya Atsumi, Masahiro Ieko, Hiroyuki Takeya, Shinsuke Yasuda, Kenji Ichikawa, Akito Tsutsumi, Koji Suzuki, and Takao Koike Blood Volume 96(4):1594-1595 August 15, 2000 ©2000 by American Society of Hematology

RVVT in 2 individuals with congenital β2GPI deficiency RVVT in 2 individuals with congenital β2GPI deficiency.(A) Russell viper venom was added to plasma samples, and clotting time was recorded. RVVT in 2 individuals with congenital β2GPI deficiency.(A) Russell viper venom was added to plasma samples, and clotting time was recorded. Both samples with β2GPI deficiency displayed a shorter clotting time. (B) One plasma sample with β2GPI deficiency was preincubated with different concentrations of exogenous β2GPI for 120 seconds at 37°C, and RVVT was recorded. Prolongation of clotting time was dose dependent in both the β2GPI-deficient plasma (●●) and a control plasma sample (○○). Rie Takeuchi et al. Blood 2000;96:1594-1595 ©2000 by American Society of Hematology