Innate B Cells Tell ILC How It’s Done

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Innate B Cells Tell ILC How It’s Done Trang T.T. Nguyen, Nicole Baumgarth Immunity Volume 45, Issue 1, Pages 8-10 (July 2016) DOI: 10.1016/j.immuni.2016.06.030 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Development and Activation of NKB Bone marrow pro B cells give rise to CD122pos NKB precursors in an Id-2-dependent manner. Activation of splenic NKBP by infections with various intracellular pathogens such as Salmonella Typhimurium and Listeria monocytogenes causes rapid activation and differentiation to IL-12 and IL-18 producing CD122neg NKB cells. These cytokines in turn trigger IFN-γ production by ILC1, including NK cells, which leads to induction of Th1 T cell responses and control of the infection. Immunity 2016 45, 8-10DOI: (10.1016/j.immuni.2016.06.030) Copyright © 2016 Elsevier Inc. Terms and Conditions