PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic

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PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic Lesley A. Kane, Richard J. Youle Cell Volume 147, Issue 4, Pages 721-723 (November 2011) DOI: 10.1016/j.cell.2011.10.028 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Miro in Mitochondrial Autophagy (A) In cells with healthy mitochondria, Miro and its binding partners connect mitochondria to microtubules, facilitating trafficking of the organelles to various cellular locations. (B) Upon mitochondrial damage, PINK1 levels are stabilized on the outer membrane, resulting in the recruitment of Parkin and modification of Miro. The inset shows the PINK1/Parkin/Miro complex described by Wang et al. (C) Through phosphorylation, ubiquitination, and proteasomal pathways, Miro is degraded. The stationary damaged mitochondrion is segregated and can then undergo mitophagy. Cell 2011 147, 721-723DOI: (10.1016/j.cell.2011.10.028) Copyright © 2011 Elsevier Inc. Terms and Conditions