Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

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Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell Volume 12, Issue 2, Pages 100-101 (August 2007) DOI: 10.1016/j.ccr.2007.07.012 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Culturing Human Breast Epithelial Cells in Standard versus the Improved Conditions The cells cultured in inadequate conditions undergo a stress-induced premature growth arrest (left side), and those cells that escape this blockade will upon experimental transformation produce tumors that contain keratin pearls, a feature of squamous cell carcinoma. In contrast, the human breast epithelial cells cultured in the improved conditions (right side) and then experimentally transformed produce tumors with well-differentiated epithelial ductal structures with central lumens typical of ductal adenocarcinoma. Drawn by Angela Diehl. Cancer Cell 2007 12, 100-101DOI: (10.1016/j.ccr.2007.07.012) Copyright © 2007 Elsevier Inc. Terms and Conditions