Applications of general multistage gatekeeping and graphical multiple testing strategies in a clinical trial setting Yihan Li, Xin Wang, Deli Wang, Walter.

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Applications of general multistage gatekeeping and graphical multiple testing strategies in a clinical trial setting Yihan Li, Xin Wang, Deli Wang, Walter Offen Contemporary Clinical Trials Volume 76, Pages 9-15 (January 2019) DOI: 10.1016/j.cct.2018.10.004 Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 1 Graphical procedures M5-M8 (as referred to in Section 3). Note: The numbers in the nodes represent the fraction of alpha initially assigned to each hypothesis. For example, ½ denotes that ½ alpha is initially assigned to the hypothesis. Contemporary Clinical Trials 2019 76, 9-15DOI: (10.1016/j.cct.2018.10.004) Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 2 Gatekeeping procedure using truncated Holm (M1, as referred to in Section 3) represented using the graphical approach. Contemporary Clinical Trials 2019 76, 9-15DOI: (10.1016/j.cct.2018.10.004) Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 3 An illustration of the different focus of gatekeeping procedures versus graphical procedures in terms of different dimensions of multiplicity. Contemporary Clinical Trials 2019 76, 9-15DOI: (10.1016/j.cct.2018.10.004) Copyright © 2018 Elsevier Inc. Terms and Conditions