Wnt/β-Catenin Signaling: Turning the Switch

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Wnt/β-Catenin Signaling: Turning the Switch Ken M. Cadigan Developmental Cell Volume 14, Issue 3, Pages 322-323 (March 2008) DOI: 10.1016/j.devcel.2008.02.006 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Speculative Model on the Role of TBL1-TBLR1 and Trabid in TCF-β-Catenin Gene Regulation In the absence of signaling (top panel), a TCF-corepressor complex silences target gene expression. When Wnt signaling causes nuclear accumulation of β-catenin (bottom panel), TBL1 and TBLR1 help recruit β-catenin to TCF at target loci, which nucleates a complex of transcriptional coactivators. APC can inhibit the TCF-β-catenin complex, and Trabid's positive role in the pathway can be explained by its ability to regulate the ubiquitination state of APC. Developmental Cell 2008 14, 322-323DOI: (10.1016/j.devcel.2008.02.006) Copyright © 2008 Elsevier Inc. Terms and Conditions