Richard C. Cook, MD, MS, Michael H

Slides:

Advertisements

Similar presentations

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies Christos G. Mihos, DO, Romain Capoulade, PhD, Evin Yucel,

Advertisements

Assessment of the Association of Bilateral Internal Thoracic Artery Skeletonization and Sternal Wound Infection After Coronary Artery Bypass Grafting

A Meta-Analysis of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement Hisato Takagi, MD, PhD, Masao Niwa, MD, Yusuke Mizuno,

Perioperative Blood Transfusion Is Associated With Worse Clinical Outcomes in Resected Lung Cancer Ting Wang, MD, Lili Luo, MD, He Huang, MD, Jingrui.

Lymphovascular Invasion as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Nathan M. Mollberg, DO,

Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD

Preoperative Prophylactic Intraaortic Balloon Pump Reduces the Incidence of Postoperative Acute Kidney Injury and Short-Term Death of High-Risk Patients.

Endosonography Versus Mediastinoscopy in Mediastinal Staging of Lung Cancer: Systematic Review and Meta-Analysis Inderpaul Singh Sehgal, MD, DM, Sahajal.

Reply The Annals of Thoracic Surgery

Robert Brewer, MD, MHSA, Patricia F. Theurer, BSN, Chad M

Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Lymph Node Dissection in Clinical Stage I Lung Cancer: A Meta-Analysis and System Review Wenxiong.

Risk-Adjusted Prolonged Length of Stay as an Alternative Outcome Measure for Pediatric Congenital Cardiac Surgery Ming Liu, MS, MA, Charlotte M. Druschel,

Postoperative Atrial Fibrillation Prophylaxis After Lung Surgery: Systematic Review and Meta-Analysis Lars Peter Riber, MD, PhD, Torben Bjerregaard Larsen,

Endovascular repair for ruptured abdominal aortic aneurysm confers an early survival benefit over open repair George A. Antoniou, MD, PhD, George S.

Rajat Kalra, MBChB, Navkaranbir S

Hisato Takagi, MD, PhD, Masafumi Matsui, MD, Takuya Umemoto, MD, PhD

Mohammed M. Uzzaman, MRCS, MS, J. Daniel Robb, FRCS, MRCP, Peter C. E

Homograft Implantation Techniques in the Aortic Position: To Preserve or Replace the Aortic Root? Thanos Athanasiou, MD, PhD, Catherine Jones, MBBS,

The Effectiveness of Postoperative Radiotherapy in Patients With Completely Resected Thymoma: A Meta-Analysis Dong Zhou, MD, Xu-Feng Deng, MD, Quan-Xing.

The Aristotle Comprehensive Complexity Score Predicts Mortality and Morbidity After Congenital Heart Surgery Mirela Bojan, MD, MS, Sébastien Gerelli,

Impact of Intravenous Magnesium on Post-Cardiothoracic Surgery Atrial Fibrillation and Length of Hospital Stay: A Meta-Analysis Nickole N. Henyan, PharmD,

Sean M. Bagshaw, MD, MS, P. Diane Galbraith, BN, MS, L

Perioperative Blood Transfusion Is Associated With Worse Clinical Outcomes in Resected Lung Cancer Ting Wang, MD, Lili Luo, MD, He Huang, MD, Jingrui.

Mustapha A. El Lakis, MD, Stephen J

Association Between Obesity and Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Operations: A Systematic Review and Meta-Analysis Adrian.

Castigliano M. Bhamidipati, DO, MS, George J

Off-Pump Versus On-Pump Coronary Revascularization: Meta-Analysis of Mid- and Long-Term Outcomes Umar A.R. Chaudhry, MBBS, Leanne Harling, MRCS, Christopher.

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies Christos G. Mihos, DO, Romain Capoulade, PhD, Evin Yucel,

Volatile anesthetics in preventing acute kidney injury after cardiac surgery: A systematic review and meta-analysis Jieru Cai, MD, Rende Xu, MD, PhD,

Beating-Heart Versus Conventional On-Pump Coronary Artery Bypass Grafting: A Meta- Analysis of Clinical Outcomes Umar A.R. Chaudhry, MBBS, Leanne Harling,

Off-Pump Coronary Artery Bypass Reduces Early Stroke in Octogenarians: A Meta- Analysis of 18,000 Patients Salah E. Altarabsheh, MD, Salil V. Deo, MS,

Outcomes of Mild to Moderate Functional Tricuspid Regurgitation in Patients Undergoing Mitral Valve Operations: A Meta-Analysis of 2,488 Patients Ibrahim.

Increased Aorto-Mitral Curtain Thickness Independently Predicts Mortality in Patients With Radiation-Associated Cardiac Disease Undergoing Cardiac Surgery

Zheng-Zhe Feng, MD, Jian Shi, MD, Xue-Wei Zhao, MD, Zhi-Fei Xu, MD

Amedeo Anselmi, MD, Gianfederico Possati, MD, Mario Gaudino, MD

Effect of statins on atrial fibrillation after cardiac surgery: A duration- and dose-response meta-analysis Wendy T. Chen, PharmD, Guru M. Krishnan,

A Meta-Analysis of Miniaturized Versus Conventional Extracorporeal Circulation in Valve Surgery Chuangshi Wang, MM, Kun Hua, PhD, Lu Yin, PhD, Yang Wang,

Surgical Lung Biopsy in Adult Respiratory Distress Syndrome: A Meta-Analysis Laura J. Libby, MD, Brian D. Gelbman, MD, Nasser K. Altorki, MD, Paul J.

The Relationship Between Hospital Surgical Case Volumes and Mortality Rates in Pediatric Cardiac Surgery: A National Sample, 1988–2005 Karl F. Welke,

Surgical Dilemmas: Diagnosis and Treatment of Atrial Plasmacytoma

A Systematic Review of Biocompatible Cardiopulmonary Bypass Circuits and Clinical Outcome Marco Ranucci, MD, Anna Balduini, AHA, Antonio Ditta, CCP,

Optimal Plasma Transfusion in Patients Undergoing Cardiac Operations With Massive Transfusion Michael A. Mazzeffi, MD, MPH, Evan Chriss, MD, Kathryn.

Jaimin R. Trivedi, MD, MPH, Allen Cheng, MD, Michele Gallo, MD, Erin M

Mallory L. Irons, MD, MBE, J. William Gaynor, MD, Thomas L

Comparison of Conservative Treatment and Thymectomy on Myasthenia Gravis Outcome Emanuela Taioli, MD, PhD, Philip Kent Paschal, Bian Liu, PhD, Andrew.

Do the EXCEL and NOBLE Trial Results Change Meta-Analysis Findings?

Meta-Analysis of Medium and Long-Term Efficacy of Loading Statins After Coronary Artery Bypass Grafting Cheng Bin, MM, Mu Junsheng, MD, Zhang Jianqun,

Yin-Shu Chang, MD, Jia-Xiang Wang, MD, PhD, Da-Wei Chang, PhD

Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD

Terry Shih, MD, Justin B. Dimick, MD, MPH

Coronary Artery Bypass Revascularization Using Bilateral Internal Thoracic Arteries in Diabetic Patients: A Systematic Review and Meta-Analysis Kan Kajimoto,

Effect of Gender After Transcatheter Aortic Valve Implantation: A Meta-Analysis Federico Conrotto, MD, Fabrizio D’Ascenzo, MD, Patrizia Presbitero, MD,

A Meta-Analysis of Postoperative Radiotherapy for Thymic Carcinoma

The Association of Chronic Lung Disease With Early Mortality and Respiratory Adverse Events After Aortic Valve Replacement Juan A. Crestanello, MD, Robert.

Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis

James W.W. Wong, MD, Koon-Hou Mak, MD, FACC

Completely Thrombosed Tricuspid Pouch Mimicking a Cardiac Tumor

Assessment of the Association of Bilateral Internal Thoracic Artery Skeletonization and Sternal Wound Infection After Coronary Artery Bypass Grafting

What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies Marco Moscarelli, MD, Khalil.

Very Prolonged Stay in the Intensive Care Unit After Cardiac Operations: Early Results and Late Survival Shuli Silberman, MD, Daniel Bitran, MD, Daniel.

Prolonged Intensive Care Unit Stay in Cardiac Surgery: Risk Factors and Long-Term- Survival Ortrud Vargas Hein, MD, Jürgen Birnbaum, MD, Klaus Wernecke,

Interinstitutional Comparison of Risk-Adjusted Mortality and Length of Stay in Congenital Heart Surgery William M. DeCampli, MD, PhD, Redmond P. Burke,

The American Board of Thoracic Surgery: Update

Impact of Cardiothoracic Resident Turnover on Mortality After Cardiac Surgery: A Dynamic Human Factor Jeffrey H. Shuhaiber, MD, Kimberley Goldsmith,

Sagar U. Nigwekar, MD, Praveen Kandula, MD, MPH

Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms Robert M. Kwee, MD Journal of Vascular.

Endovascular repair for ruptured abdominal aortic aneurysm confers an early survival benefit over open repair George A. Antoniou, MD, PhD, George S.

Hisato Takagi, MD, PhD, Masafumi Matsui, MD, Takuya Umemoto, MD, PhD

The Impact of New Technology on Cardiothoracic Surgical Practice

Induction Chemoradiation Is Not Superior to Induction Chemotherapy Alone in Stage IIIA Lung Cancer Asad A. Shah, MD, Mark F. Berry, MD, Ching Tzao, MD,

Presentation transcript:

Prophylactic Magnesium Does Not Prevent Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis Richard C. Cook, MD, MS, Michael H. Yamashita, MDCM, MPH, Mark Kearns, MD, Krishnan Ramanathan, MB, ChB, Ken Gin, MD, Karin H. Humphries, DSc The Annals of Thoracic Surgery Volume 95, Issue 2, Pages 533-541 (February 2013) DOI: 10.1016/j.athoracsur.2012.09.008 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow diagram to illustrate identification, selection, and exclusion of trials used in the primary meta-analysis. The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plot of the random-effects meta-analysis of 21 studies of magnesium (Mg) for the prevention of atrial fibrillation after cardiac surgery. Point estimates, 95% confidence intervals (CI), and study weights are provided for each study. (ID = identifier; OR = odds ratio.) The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Funnel plot of the 21 studies included in the primary meta-analysis of magnesium for the prevention of atrial fibrillation after cardiac surgery. The precision of each study (standard error of the log odds ratio [OR]) is plotted against each study's effect estimate (OR). (B) Egger plot for the occurrence of atrial fibrillation. Egger's linear regression line, plotted on the Galbraith radial plot. Standard normal deviate (SND) is the odds ratio of each study divided by its standard error. The standard normal deviate is regressed against precision, which is the inverse of the standard error for each study. (CI = confidence interval.) The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 (A) Dose-response curve for total dose of magnesium given. Log (odds ratio [OR]) is plotted against the total dose of magnesium administered in each study. Slope of the line describes the dose-response relationship. (B) Dose-response curve for duration of magnesium therapy. Log (OR) is plotted against the duration of time magnesium was administered in each study. Slope of the line describes the dose-response relationship. The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Forest plot of the five high-quality randomized, controlled trials. Model is a random-effects model with odds ratio (OR) point estimates, 95% confidence intervals (CI), and study weights for each study. The “diamond” provides the summary odds ratio for the model. (ID = identifier; Mg = magnesium.) The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Forest plot of the random-effects model displaying the effect of magnesium on stroke (as defined by the study authors; n = 3 studies). Odds ratio (OR) point estimates, 95% confidence intervals (CI), and study weights are provided for each study. The “diamond” provides the summary odds ratio for the model. (ID = identifier; Mg = magnesium.) The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 Forest plot of the random-effects model displaying the effect of magnesium on mortality (30-day or in-hospital, as defined by the study authors; n = 9 studies). Odds ratio (OR) point estimates, 95% confidence intervals (CI), and study weights are provided for each study. The “diamond” provides the summary odds ratio for the model. (ID = identifier; Mg = magnesium.) The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 8 Forest plot of the weighted mean difference (WMD) for length of stay (n = 9 studies). The “diamond” is the summary estimate from the random-effects model of the mean different length of stay associated with magnesium use. (CI = confidence interval; ID = identifier; Mg = magnesium.) The Annals of Thoracic Surgery 2013 95, 533-541DOI: (10.1016/j.athoracsur.2012.09.008) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions