AJKD Atlas of Renal Pathology: Fibrillary Glomerulonephritis

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AJKD Atlas of Renal Pathology: Fibrillary Glomerulonephritis Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E. Alpers, MD American Journal of Kidney Diseases Volume 66, Issue 4, Pages e27-e28 (October 2015) DOI: 10.1053/j.ajkd.2015.08.002 Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Fibrillary glomerulonephritis with moderate mesangial proliferation and occasional double contours of the glomerular basement membrane (Jones silver stain). Reproduced with permission from AJKD 33(2):e1. American Journal of Kidney Diseases 2015 66, e27-e28DOI: (10.1053/j.ajkd.2015.08.002) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Fibrillary glomerulonephritis with cellular crescent (Jones silver stain). Reproduced with permission from AJKD 33(2):e1. American Journal of Kidney Diseases 2015 66, e27-e28DOI: (10.1053/j.ajkd.2015.08.002) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Fibrillary glomerulonephritis with smudgy positivity in the mesangium and capillary loops. The most common staining is polyclonal immunoglobulin G (IgG), often with dominant subtype IgG4 (immunofluorescence microscopy, IgG). Reproduced with permission from AJKD 33(2):e1. American Journal of Kidney Diseases 2015 66, e27-e28DOI: (10.1053/j.ajkd.2015.08.002) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Fibrillary glomerulonephritis shows randomly arranged fibrils in the mesangial and capillary loop areas including subepithelial, intramembranous, and subendothelial locations (electron microscopy). Reproduced with permission from AJKD 33(2):e1. American Journal of Kidney Diseases 2015 66, e27-e28DOI: (10.1053/j.ajkd.2015.08.002) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 5 Fibrils in fibrillary glomerulonephritis are randomly arranged and are typically 12-22 nm in diameter (electron microscopy). Reproduced with permission from AJKD 33(2):e1. American Journal of Kidney Diseases 2015 66, e27-e28DOI: (10.1053/j.ajkd.2015.08.002) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions