Metabolic Phenotyping in Health and Disease

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

Profiling by Image Registration Reveals Common Origin of Annelid Mushroom Bodies and Vertebrate Pallium Raju Tomer, Alexandru S. Denes, Kristin Tessmar-Raible,

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Plant Stomata Function in Innate Immunity against Bacterial Invasion Maeli Melotto, William Underwood, Jessica Koczan, Kinya Nomura, Sheng Yang He Cell.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

The Monarch Butterfly Genome Yields Insights into Long-Distance Migration Shuai Zhan, Christine Merlin, Jeffrey L. Boore, Steven M. Reppert Cell Volume.

Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells Wang Nguitragool, Abdullah A.B. Bokhari, Ajay D. Pillai,

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

P120-Catenin Mediates Inflammatory Responses in the Skin Mirna Perez-Moreno, Michael A. Davis, Ellen Wong, H. Amalia Pasolli, Albert B. Reynolds, Elaine.

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine Ken Cadwell, Khushbu K. Patel, Nicole S. Maloney,

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

ZIKA App – A great resource from the World Health Organization (WHO)

Sex-Specific Aging in Flies, Worms, and Missing Great-Granddads

Elaine Holmes, Jia V. Li, Julian R. Marchesi, Jeremy K. Nicholson

Elaine Holmes, Jia V. Li, Thanos Athanasiou, Hutan Ashrafian, Jeremy K

Unweaving the Autism Spectrum

Breathe in and Straighten Your Back: Hypoxia, Notch, and Scoliosis

Volume 13, Issue 1, Pages 5-6 (January 2011)

Chronic Infections Capture Little Attention of the Masses

Mapping Human Epigenomes

Redefining Clinical Trials: The Age of Personalized Medicine

William J. Blake, James J. Collins Cell

Wenlian Qiao, Peter W. Zandstra Cell Stem Cell

The Whole (Cell) Is Less Than the Sum of Its Parts

In This Issue Cell Volume 158, Issue 5, (August 2014)

Volume 131, Issue 1, Pages (October 2007)

FIX It in One Go: Enhanced Factor IX Gene Therapy for Hemophilia B

Volume 13, Issue 1, Pages 5-6 (January 2011)

Volume 25, Issue 3, Pages (March 2017)

Gender Differences Among Long-Distance Backpackers: A Prospective Study of Women Appalachian Trail Backpackers David R. Boulware, MD Wilderness & Environmental.

Chronic Infections Capture Little Attention of the Masses

Volume 152, Issue 1, (January 2013)

Branching Out for Detection of Type 2 Diabetes

The Many Faces of PPARγ Cell

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Volume 130, Issue 6, (September 2007)

Need for Speed: Mechanical Regulation of a Replicative Helicase

Modeling Transcriptome Dynamics in a Complex World

Gizem Donmez, Diana Wang, Dena E. Cohen, Leonard Guarente Cell

Volume 143, Issue 6, (December 2010)

Making the Most from Changes in Life

The Plasticity of Aging: Insights from Long-Lived Mutants

Learning from the Uncontrollable

Volume 163, Issue 4, (November 2015)

Volume 163, Issue 2, (October 2015)

Chapter 77 Cervical Cancer: Burden of Disease

Volume 134, Issue 6, (September 2008)

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Presentation transcript:

Metabolic Phenotyping in Health and Disease Elaine Holmes, Ian D. Wilson, Jeremy K. Nicholson Cell Volume 134, Issue 5, Pages 714-717 (September 2008) DOI: 10.1016/j.cell.2008.08.026 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Interactions between Genes and the Environment and Their Effects on Health Metabolic phenotypes (metabotypes) can be measured by profiling small molecules (<1 kDa) in biofluids (usually urine or blood) by spectroscopic techniques such as NMR. Metabolic phenotypes are influenced by intrinsic and environmental factors that determine health status and disease risk of an individual or group. Measuring and modeling the profile of all metabolites (metabolome) in an individual may provide insights into disease risk factors and etiology, information that could be used for personalized medicine. Cell 2008 134, 714-717DOI: (10.1016/j.cell.2008.08.026) Copyright © 2008 Elsevier Inc. Terms and Conditions