A Pause to Splice Molecular Cell Pia K. Andersen, Torben Heick Jensen  Molecular Cell  Volume 40, Issue 4, Pages 503-505 (November 2010) DOI: 10.1016/j.molcel.2010.11.019 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 RNAPII Pausing-Assisted mRNA Processing RNAPII pausing during transcription initiation allows for nascent RNA capping by the Cet1p, Abd1p, and Ceg1p capping factors, of which the two latter bind the RNAPII CTD. RNAPII pausing after the pA site allows for RNA 3′ end formation by the CPF and CFIA complexes. The latter includes the CTD-binding factor Pcf11p. It is now shown that RNAPII pausing near the 3′ splice site (3′SS) may allow for cotranscriptional splicing. Red signs (II) on the gene indicate RNAPII pause sites. U1/U2, U1 and U2 snRNPs that are recruited to 5′SS and 3′SS, respectively; EF, export factor. See the main text for more detail. Molecular Cell 2010 40, 503-505DOI: (10.1016/j.molcel.2010.11.019) Copyright © 2010 Elsevier Inc. Terms and Conditions