In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

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In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles? Yuan Zhang, Andrew Satterlee, Leaf Huang  Molecular Therapy  Volume 20, Issue 7, Pages 1298-1304 (July 2012) DOI: 10.1038/mt.2012.79 Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions

Figure 1 Representative scheme of in vivo gene delivery barriers. EPR, enhanced permeability and retention; mRNA, messenger RNA; PEG, polyethylene glycol; RES, reticuloendothelial system; RISC, RNA-induced silencing complex; siRNA, small interfering RNA. Molecular Therapy 2012 20, 1298-1304DOI: (10.1038/mt.2012.79) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions

Figure 2 The structure and preparation scheme of LPD (LPD-II)/LPH nanoparticles. LPD, liposome-polycation-DNA; LPH, liposome-polycation-hyaluronic acid (or heparin); pDNA, plasmid DNA; PEG, polyethylene glycol; siRNA, small interfering RNA. Molecular Therapy 2012 20, 1298-1304DOI: (10.1038/mt.2012.79) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions

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