Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy  W. Nathaniel Brennen, John T. Isaacs  Cancer Cell  Volume 32, Issue 4, Pages 399-401 (October 2017) DOI: 10.1016/j.ccell.2017.09.011 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Prostate Cell Lineage, Cancer-Initiating Cells, and Therapeutic Selection Overview of the cellular subtypes within the hierarchically expanding stem cell organization of the normal human prostate epithelial compartment based on the characteristic self-renewal potential, proliferation rate, and phenotypic marker expression. Magnitude of self- renewal potential versus proliferation rate for each subtype is indicated by the number of “+” signs, indicating increasing values, and “−” signs, indicating a zero value. Phenotypic markers are: androgen receptor (AR), prostate-specific antigen (PSA), TP63, and neuroendocrine (NE) genes (i.e., chromogranin A, synaptophysin, etc.), with superscript “+” indicating expression and superscript “−” indicating no expression. Cancer Cell 2017 32, 399-401DOI: (10.1016/j.ccell.2017.09.011) Copyright © 2017 Elsevier Inc. Terms and Conditions