Volume 388, Issue 10061, Pages (December 2016)

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Volume 388, Issue 10061, Pages 2753-2762 (December 2016) Intratympanic methylprednisolone versus gentamicin in patients with unilateral Ménière's disease: a randomised, double-blind, comparative effectiveness trial  Mitesh Patel, PhD, Kiran Agarwal, MD, Qadeer Arshad, PhD, Mohamed Hariri, MD, Peter Rea, MD, Barry M Seemungal, MD, Prof John F Golding, PhD, Jonny P Harcourt, MD, Prof Adolfo M Bronstein, MD  The Lancet  Volume 388, Issue 10061, Pages 2753-2762 (December 2016) DOI: 10.1016/S0140-6736(16)31461-1 Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 Trial profile The Lancet 2016 388, 2753-2762DOI: (10.1016/S0140-6736(16)31461-1) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 Mean number of attacks of vertigo 6 months before treatment and in the final 6 months Bars are SDs. The Lancet 2016 388, 2753-2762DOI: (10.1016/S0140-6736(16)31461-1) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 3 Mean number of attacks of vertigo in the 1 month before treatment and in the final 1 month Bars are SDs. The Lancet 2016 388, 2753-2762DOI: (10.1016/S0140-6736(16)31461-1) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 4 Mean scores for (A) Vertigo Symptom Scale, (B) Dizziness Handicap Inventory, (C) Functional Level Scale, (D) Tinnitus Handicap Inventory, and (E) Aural Fullness Scale at each timepoint Bars are SDs. The Lancet 2016 388, 2753-2762DOI: (10.1016/S0140-6736(16)31461-1) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 5 Mean (A) low-frequency pure tone audiometry level and (B) speech discrimination threshold over the 24-month follow-up Bars are SDs. The Lancet 2016 388, 2753-2762DOI: (10.1016/S0140-6736(16)31461-1) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions