Dihydromyricetin decreases the sphere formation through downregulation of Sox2 in human osteosarcoma. Dihydromyricetin decreases the sphere formation through.

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Dihydromyricetin decreases the sphere formation through downregulation of Sox2 in human osteosarcoma. Dihydromyricetin decreases the sphere formation through downregulation of Sox2 in human osteosarcoma. A, osteosphere assay of osteosarcoma cells treated with dihydromyricetin. Results from a representative experiment are shown. Similar results were obtained with the U2OS, U2OS/MTX, and 143B cells. B and C, Sox2 expression was analyzed by real-time PCR and Western blot in U2OS, U2OS/MTX, and 143B cells treated with dihydromyricetin. D, subcellular localization of Sox2 in the U2OS treated with dihydromyricetin. E, PcDNA3.1 and SOX2/GFP plasmid were transfected into U2OS treated with or without dihydromyricetin, and Sox2 expression was detected by Western blotting. F, osteosphere assay of U2OS as in E was performed, and spheres were counted after 2 weeks. G, Sox2 expression on animal samples was detected by IHC. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Zhiqiang Zhao et al. Cancer Prev Res 2014;7:927-938 ©2014 by American Association for Cancer Research