High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

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High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). The color of circles is related to percent of methylation in each CpG site. Arrows show the different methylation pattern between cancerous tissues and adjacent normal tissues (left pictures). Right pictures are two-way hierarchical cluster analysis of 48 cancerous breast tissues and 48 normal breast tissues. Ramin Radpour et al. Mol Cancer Res 2008;6:1702-1709 ©2008 by American Association for Cancer Research