Days after cell inoculation Days after cell inoculation

Slides:

Advertisements

Similar presentations

Counts TLR3-PE Counts TLR8-PE Counts TLR9-PE C AB Supplemental Figure 1.

Advertisements

Figure 1.1 The observer in the truck sees the ball move in a vertical path when thrown upward. (b) The Earth observer views the path of the ball as a parabola.

The reading is 7.38 mm. The reading is 7.72 mm.

Silencing miR-106b accelerates osteogenesis of mesenchymal stem cells and rescues against glucocorticoid-induced osteoporosis by targeting BMP2 Ke Liu,

Enhanced Reactive Oxygen Species Production, Acidic Cytosolic pH and Upregulated Na+/H+ Exchanger (NHE) in Dicer Deficient CD4+

A Novel Cinnamide YLT26 Induces Breast Cancer Cells Apoptosis via ROS-Mitochondrial Apoptotic Pathway in Vitro and Inhibits.

a GM DM1 DM3 DM5 DM7 b MHC MHC +DAPI GM DM4

Cell Physiol Biochem 2016;38: DOI: /

Downregulation of MicroRNA-145 Caused by Hepatitis B Virus X Protein Promotes Expression of CUL5 and Contributes to Pathogenesis of Hepatitis B Virus-Associated.

Potential Molecular Mechanisms for Improved Prognosis and Outcome with Neoadjuvant Chemotherapy Prior to Laparoscopical Radical Hysterectomy for Patients.

0 Gy NSC NSC 5 Gy NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC

MicroRNA-101 Inhibits Growth, Proliferation and Migration and Induces Apoptosis of Breast Cancer Cells by Targeting Sex-Determining Region Y-Box 2 Cell.

Ctrl IR, 2h G2 P53 Ser15 S G1 G2 S G1 Figure S1. The bivariate (phospho-p53 Ser15 vs DNA content) distribution of control and irradiated with 6 Gy mESCs.

From: MicroRNA-200b Downregulates Oxidation Resistance 1 (Oxr1) Expression in the Retina of Type 1 Diabetes Model Invest. Ophthalmol. Vis. Sci ;54(3):

Fig. 2. The effect of miR-379 on cell proliferation, invasion, migration, and apoptosis of VSMCs. Twenty-four hours after cells were transfected with miR-379.

Effect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small.

1α,25-Dihydroxycholecalciferol (Vitamin D3) Induces NO-Dependent Endothelial Cell Proliferation and Migration in a Three-Dimensional Matrix Cell Physiol.

a b c ** ** ** ** * * * P450arom mRNA Trascript Levels (Fold)

Online Gifts Buy for wishes happy mother's day to yours choice and with happy gifts find here:

Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death S. D'Adamo,

Volume 145, Issue 2, Pages (August 2013)

expression surface markers

Volume 191, Issue 1, Pages (January 2014)

Angiogenesis Inhibitors

Supplementary Figure S1

Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs McDermott Niamh , Meunier Armelle , Wong Simon , Buchete.

Relative expression ratio Relative expression ratio

MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses F. Meng, Z. Zhang, W.

Days after cell inoculation Days after cell inoculation

Supplementary Figure 1 Non-migrating cells Migrating cells

Supplementary Figure 2. Effect of IL-32 and siRNA of IL-32 on melanoma, colon and prostate cancer cell growth and apoptosis as well as IL-32 expression.

LNCaP * C4-2B Du145 22Rv1 SI Figure 1. miR-124 inhibits the proliferation of CaP cells. WST-1 cell proliferation analysis of AR-positive CaP cell lines.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Volume 145, Issue 2, Pages (August 2013)

Molecular Therapy - Nucleic Acids

8 slides for 4 panels (A-D)

AE1/AE3 Rabbit Normal IgG Supplementary Figure S1 White bar = 5 mm

S. D'Adamo, O. Alvarez-Garcia, Y. Muramatsu, F. Flamigni, M.K. Lotz

b. Bone marrow (CP) IM sensitive c. Bone marrow (CP) IM resistant

Fig. 5. GUCD1 was a direct target of miR-370 in HCC

Fig. 8 Combining M7824 with radiation or chemotherapy enhances antitumor efficacy. Combining M7824 with radiation or chemotherapy enhances antitumor efficacy.

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK

Anti-tumor effect of anti-PD-1 antibody against SCC3 tumor

Supplementary Fig. S1 BCL2 5’flanking ctrl siRNA luc

miR-330-5p Targets Tyrosinase and Induces Depigmentation

CD137/NFATc1 Axis Was Directly Targeted by miR-145 (A) Relative mRNA expression levels of NFATc1 and CD137 in the miR-145 mimic- or inhibitor-treated group.

Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

C A B * * * * HCC1954 HCC1569 Supplementary-Figure S5 Tumor cells sc.

Induction of apoptosis by nelfinavir and bortezomib

Rice lines carrying Xa13 Rice lines carrying xa13

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

Supplemental Figure 1 Cell proliferation (% of mock)

A B C D E F Supplementary Fig. 3. Gating strategy for ES2 ALDHhi tumor initiating cells (TIC). Cells were treated with the specific aldehyde dehydrogenase.

Fig. 8 Combining M7824 with radiation or chemotherapy enhances antitumor efficacy. Combining M7824 with radiation or chemotherapy enhances antitumor efficacy.

PKIs block DHT + bombesin-induced transactivation of probasin ARR3 tk-luc and PSA pPUE-E1b-Luc report constructs. PKIs block DHT + bombesin-induced transactivation.

MiR-431-5p directly targets RAF1 and is negatively correlated to RAF1 expression (A) The predicted binding sites of miR-431-5p and RAF1 3′-UTR, and mutant.

FBXL19-AS1 acts as a sponge of miR-431-5p in lung cancer (A) The predicted binding sites of FBXL19-AS1 and miR-431-5p, and the mutant sites in mutant-type.

The Expression of MicroRNA-598 Inhibits Ovarian Cancer Cell Proliferation and Metastasis by Targeting URI Feng Xing, Shuo Wang, Jianhong Zhou Molecular.

Protection from 4T1 tumor rechallenge in treated mice.

Molecular Therapy - Nucleic Acids

Fig. 6 RUNX/CBFB interaction inhibitor, Ro5-3335, significantly decreases mouse neurofibroma growth in vivo. RUNX/CBFB interaction inhibitor, Ro5-3335,

Antitumor immunity caused by DS-8201a.

The responses of H292 and A549 lung cancer xenografts to hypofractionated radiation were enhanced by the ketogenic diet. The responses of H292 and A549.

Activity of a chemically modified miR-21 inhibitor in human bladder cancer xenografts. Activity of a chemically modified miR-21 inhibitor in human bladder.

SW620 xenografts treated with combination siKRAS+siPIK3CA/B.

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Validation of KMT2D function in MM23, MM2, and MM25 PDXs

Ceritinib is a potent ALK inhibitor in crizotinib-naïve models.

Presentation transcript:

Days after cell inoculation Days after cell inoculation Supplementary Fig. 3 A B C SW-480/OR SW-480/OR SW-480/OR Naïve Mimic NC miR-34a mimic Naïve Mimic NC miR-34a mimic b a a a a c a a a Relative expression (miR-34a/U6) b Cell survival (%) Apoptosis (OD @ 405nm) c b b b b a a b a a a Naïve 0 10 20 0 10 20 Mimic NC miR-34a mimic Oxaliplatin (μM) Oxaliplatin (μM) D E F SW-480/OR SW-480 SW-480 Naïve Mimic NC miR-34a mimic Naïve Inhibitor NC miR-34a inhibitor a a a a Relative expression (miR-34a/U6) a a b b d Cell survival (%) Tumor volume (mm3) b c c ** * * Naïve 0 10 20 Inhibitor NC 8 16 20 24 28 miR-34a inhibitor Oxaliplatin (μM) Days after cell inoculation G SW-480 H SW-480 Naïve Inhibitor NC miR-34a inhibitor Naïve Inhibitor NC miR-34a inhibitor c * c ** Apoptosis (OD @ 405nm) Tumor volume (mm3) b b a d a a a 0 10 20 8 16 20 24 28 Oxaliplatin (μM) Days after cell inoculation