Days after cell inoculation Days after cell inoculation

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Days after cell inoculation Days after cell inoculation

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Days after cell inoculation Days after cell inoculation Supplementary Fig. 2 A B C HCT-116/OR HCT-116/OR HCT-116/OR Naïve Mimic NC miR-34a mimic Naïve Mimic NC miR-34a mimic b a d a a a a Relative expression (miR-34a/U6) a a Apoptosis (OD @ 405nm) b c Cell survival (%) c a b a b b b a a a Naïve Mimic NC 0 10 20 0 10 20 miR-34a mimic Oxaliplatin (μM) Oxaliplatin (μM) D E F HCT-116/OR HCT-116 HCT-116 Naïve Inhibitor NC miR-34a inhibitor Naïve Mimic NC miR-34a mimic a a a a a a a Relative expression (miR-34a/U6) b b Cell survival (%) Tumor volume (mm3) b c c * * Naïve 8 16 20 24 28 Inhibitor NC 0 10 20 Days after cell inoculation miR-34a inhibitor Oxaliplatin (μM) G H HCT-116 HCT-116 Naïve Inhibitor NC miR-34a inhibitor Naïve Inhibitor NC miR-34a inhibitor d ** d ** Apoptosis (OD @ 405nm) Tumor volume (mm3) * b b c c a a a 0 10 20 8 16 20 24 28 Oxaliplatin (μM) Days after cell inoculation