Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome

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Presentation transcript:

Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome Christine Cortet-Rudelli, M.D., Pascal Pigny, Ph.D., Christine Decanter, M.D., Maryse Leroy, M.D., Catherine Maunoury-Lefebvre, M.D., Patricia Thomas-Desrousseaux, M.D., Didier Dewailly, M.D. Fertility and Sterility Volume 77, Issue 2, Pages 281-287 (February 2002) DOI: 10.1016/S0015-0282(01)02968-5

FIGURE 1 Relationship between BMI and serum inhibin B level in control patients (dotted line, n = 78) and in patients with PCOS (solid line, n = 134). See Table 2 for the values of the Pearson coefficient of correlation. Cortet-Rudelli. Inhibin B, obesity, and LH in PCOS. Fertil Steril 2002. Fertility and Sterility 2002 77, 281-287DOI: (10.1016/S0015-0282(01)02968-5)

FIGURE 2 Relationship between serum LH and inhibin B levels in nonobese (solid line, P<.01) and in obese (dotted line, P=.22) patients with PCOS. Cortet-Rudelli. Inhibin B, obesity, and LH in PCOS. Fertil Steril 2002. Fertility and Sterility 2002 77, 281-287DOI: (10.1016/S0015-0282(01)02968-5)

FIGURE 3 Diagram of the putative cooperation between TICs and GCs in the production of inhibin B by PCOs. See the Discussion for explanation. A, androstenedione; α-SU, inhibin α-subunit; βB-SU, inhibin βB-subunit. Cortet-Rudelli. Inhibin B, obesity, and LH in PCOS. Fertil Steril 2002. Fertility and Sterility 2002 77, 281-287DOI: (10.1016/S0015-0282(01)02968-5)