Lauren E. Higdon, Michael P. Cancro Immunity

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Presentation transcript:

Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation Lauren E. Higdon, Michael P. Cancro Immunity Volume 43, Issue 1, Pages 5-6 (July 2015) DOI: 10.1016/j.immuni.2015.07.002 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Alternative Routes and Locales for Antibody Affinity Maturation Top: In a conventional T cell-dependent response, B cells activated by avid BCR engagement receive cognate T cell help and form GCs, where their interactions with FDCs and Tfh enable rounds of somatic hypermutation and selection that yield high-affinity plasma and memory B cells. Bottom: The response to STm initiates with comparatively low affinity B cells, which undergo SHM and affinity maturation in the absence of GCs. Immunity 2015 43, 5-6DOI: (10.1016/j.immuni.2015.07.002) Copyright © 2015 Elsevier Inc. Terms and Conditions