Volume 135, Issue 6, Pages 1945-1952 (December 2008) The Natural History of Serum Iron Indices for HFE C282Y Homozygosity Associated With Hereditary Hemochromatosis  Lyle C. Gurrin, Nicholas J. Osborne, Clare C. Constantine, Christine E. McLaren, Dallas R. English, Dorota M. Gertig, Martin B. Delatycki, Melissa C. Southey, John L. Hopper, Graham G. Giles, Gregory J. Anderson, John K. Olynyk, Laurie W. Powell, Katrina J. Allen  Gastroenterology  Volume 135, Issue 6, Pages 1945-1952 (December 2008) DOI: 10.1053/j.gastro.2008.08.056 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 The percentage of C282Y homozygous participants (male and female) whose serum ferritin (SF) and transferrin saturation (TS) measurements exceed the upper limit of the clinical thresholds at (A) baseline and (B) follow-up. The “T-bars” above and below observed percentages encapsulate a 95% confidence interval for the population percentage. “Elevated SF” is >300 μg/L for males and postmenopausal females and >200 μg/L for premenopausal females. “Elevated TS” is >50% for males and >45% for females. All SF and TS measurements contributing to these percentages are pretreatment. Gastroenterology 2008 135, 1945-1952DOI: (10.1053/j.gastro.2008.08.056) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Baseline (open circles) and follow-up (solid circles) serum ferritin (SF) plotted against age for (A) males, (B) premenopausal females, and (C) postmenopausal females who are C282Y homozygotes. Observations on those who were untreated until after follow-up and who contributed SF measures at both baseline and follow-up are joined by a dashed line segment. Gastroenterology 2008 135, 1945-1952DOI: (10.1053/j.gastro.2008.08.056) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Predicted probabilities that serum ferritin (SF) at follow-up exceeds each of 3 clinically relevant thresholds (300 μg/L, 500 μg/L, 1000 μg/L) given the value of baseline SF for untreated C282Y homozygotes. Panel A is for males stratified by baseline transferrin saturation (TS). Panel B is for females stratified by menopausal status at baseline. Gastroenterology 2008 135, 1945-1952DOI: (10.1053/j.gastro.2008.08.056) Copyright © 2008 AGA Institute Terms and Conditions