Fig. 1 Increasing UCB cell dose impairs short-term progenitor cell engraftment. Increasing UCB cell dose impairs short-term progenitor cell engraftment.

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Presentation transcript:

Fig. 1 Increasing UCB cell dose impairs short-term progenitor cell engraftment. Increasing UCB cell dose impairs short-term progenitor cell engraftment. (A) Experimental scheme. (B) Fold changes in CD34+ and CD34+CD45RA−CD90+ hematopoietic stem cell–enriched (HSC-e) cells [calculated as cell number harvested from bone marrow (BM) of two femurs and two tibiae in relation to the number injected on day 0; see table S1 for the cellular composition of the purified CD34+ fraction and unfractionated umbilical cord blood (UCB) cells and table S2 for the cell number transplanted on day 0]. Dots represent individual mice, with horizontal lines denoting the mean values (n = 5 mice per group from one experiment). Two-tailed Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction (Padj = 0.992) were used to determine the significance level. *P < 0.05; **P < 0.01; and ***P < 0.001. (C) Heat map representation of the percentage of human cell subsets (gated on 7-AAD−CD45+HLA-ABC+) detected in the mouse BM (see table S3 for phenotypic definition and table S4 for P values). Weijia Wang et al., Sci Transl Med 2017;9:eaag3214 Published by AAAS