The role of progenitor cells in the development of intimal hyperplasia

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The role of progenitor cells in the development of intimal hyperplasia Shirling Tsai, MD, Jason Butler, PhD, Shahin Rafii, MD, Bo Liu, PhD, K. Craig Kent, MD Journal of Vascular Surgery Volume 49, Issue 2, Pages 502-510 (February 2009) DOI: 10.1016/j.jvs.2008.07.060 Copyright © 2009 The Society for Vascular Surgery Terms and Conditions

Fig 1 Schematic of stem cell and progenitor cell classification. The hemangioblast is believed to be an embryonic precursor for HSCs and possibly also EPCs. HSCs differentiate into hematopoietic progenitors and then into the various blood cell lineages, but there is also evidence that HSCs can transdifferentiate into non-hematopoietic cells. MSCs are believed to differentiate into multiple mesenchymal lineages. Dotted grey lines indicate points that are still controversial. Journal of Vascular Surgery 2009 49, 502-510DOI: (10.1016/j.jvs.2008.07.060) Copyright © 2009 The Society for Vascular Surgery Terms and Conditions

Fig 2 Schematic of the contribution of progenitor cells and local factors to the re-population of the neointima after arterial injury. EC, Endothelial cell; IEL, internal elastic lamina; EEL, external elastic lamina. Journal of Vascular Surgery 2009 49, 502-510DOI: (10.1016/j.jvs.2008.07.060) Copyright © 2009 The Society for Vascular Surgery Terms and Conditions