Effects of off-pump versus on-pump coronary artery bypass grafting on function and viability of circulating endothelial progenitor cells Marc Ruel, MD,

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Presentation transcript:

Effects of off-pump versus on-pump coronary artery bypass grafting on function and viability of circulating endothelial progenitor cells Marc Ruel, MD, MPH, Erik J. Suuronen, PhD, Jianming Song, MD, MSc, Varun Kapila, BSc, Derek Gunning, MD, Geeta Waghray, BSc, Fraser D. Rubens, MD, MSc, Thierry G. Mesana, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 130, Issue 3, Pages 633-639 (September 2005) DOI: 10.1016/j.jtcvs.2005.01.013 Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Endothelial progenitor cells 24 hours after surgery (original magnification, 400×). Mononuclear cells isolated from the peripheral blood (in this example, from an OPCAB patient) were characterized as endothelial progenitor cells if they exhibited spindle-shape endothelial cell–like morphology and stained double-positive for lectin binding (green) and labeled acetylated low-density lipoprotein (red). The Journal of Thoracic and Cardiovascular Surgery 2005 130, 633-639DOI: (10.1016/j.jtcvs.2005.01.013) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Migration assays of cultured human EPCs (original magnification, 100×). Photomicrographs of day 7 cultured EPCs harvested 24 hours after surgery from on-pump CABG and OPCAB patients. There was improved EPC migration in samples from the OPCAB compared with the on-pump patients (P = .04; see text). Also shown are day 7 cultured EPCs harvested from a healthy volunteer who did not undergo operation. The postoperative EPC migratory activity of OPCAB patients was also higher than that of healthy volunteers, but this difference was not statistically significant (P = .05; see text). The Journal of Thoracic and Cardiovascular Surgery 2005 130, 633-639DOI: (10.1016/j.jtcvs.2005.01.013) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Endothelial progenitor cell (EPC) nonviability after on-pump CABG versus OPCAB. On-pump CABG and OPCAB had no significant difference in EPC viability before surgery. However, postoperative viability, the absolute increase in nonviability, and the mean postoperative-preoperative EPC nonviability ratio were significantly higher in patients who underwent on-pump CABG than in those who underwent OPCAB. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 633-639DOI: (10.1016/j.jtcvs.2005.01.013) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions