Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function Pia Reece, BSc, Amudhinie Thanendran, BSc,

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Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function Pia Reece, BSc, Amudhinie Thanendran, BSc, Lynn Crawford, BSc, Meri K. Tulic, PhD, Lehana Thabane, PhD, Susan L. Prescott, PhD, MD, Roma Sehmi, PhD, Judah A. Denburg, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 2, Pages 447-453 (February 2011) DOI: 10.1016/j.jaci.2010.11.006 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Differential CB CD34+ progenitor cell expression of TLR-2, TLR-4, and TLR-9 between high- and low-risk infants. CB mononuclear cells from high- and low-risk infants were stained with antibodies to surface TLR-2 and TLR-4 and intracellular TLR-9. CD34+ progenitor cells were gated and analyzed for differences in TLR expression. Data are presented as geometric means (95% CIs), and significant findings are indicated on the graph. Journal of Allergy and Clinical Immunology 2011 127, 447-453DOI: (10.1016/j.jaci.2010.11.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Differential CB CD34+ progenitor cell expression of IL-3Rα, IL-5Rα, and GM-CSFRα between high- and low-risk infants. CB mononuclear cells from high- and low-risk infants were stained with antibodies to surface IL-3Rα, IL-5Rα, and GM-CSFRα. CD34+ progenitor cells were gated and analyzed for differences in hematopoietic cytokine receptor expression. Data are presented as geometric means (95% CIs), and significant findings are indicated on the graph. Journal of Allergy and Clinical Immunology 2011 127, 447-453DOI: (10.1016/j.jaci.2010.11.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Responses to hematopoietic cytokines (IL-3) with or without LPS costimulation of CB CD34+ progenitor cells in high- and low-risk infants. CB mononuclear cells from low- and high-risk infants were enriched for CD34+ cells and stimulated with the hematopoietic cytokine IL-3 (1 ng/mL) or IL-3 and LPS (10 μg/mL) for 14 days (5% CO2 in 37°C). Data are presented as means ± SEMs, and significant findings are indicated on the graph. Journal of Allergy and Clinical Immunology 2011 127, 447-453DOI: (10.1016/j.jaci.2010.11.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Responses to hematopoietic cytokine (IL-5) with or without LPS costimulation of CB CD34+ progenitor cells in high- and low-risk infants. CB mononuclear cells from low- and high-risk infants were enriched for CD34+ cells and stimulated with the hematopoietic cytokine IL-5 (1 ng/mL) or IL-5 and LPS (10 μg/mL) for 14 days (5% CO2 in 37°C). Data are presented as means ± SEMs, and significant findings are indicated on the graph. Journal of Allergy and Clinical Immunology 2011 127, 447-453DOI: (10.1016/j.jaci.2010.11.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Responses to hematopoietic cytokine (GM-CSF) with or without LPS costimulation of CB CD34+ progenitor cells in high- and low-risk infants. CB mononuclear cells from low- and high-risk infants were enriched for CD34+ cells and stimulated with the hematopoietic cytokine GM-CSF (10 ng/mL) or GM-CSF and LPS (10 μg/mL) for 14 days (5% CO2 in 37°C). Data are presented as means ± SEMs, and significant findings are indicated on the graph. Journal of Allergy and Clinical Immunology 2011 127, 447-453DOI: (10.1016/j.jaci.2010.11.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions