Dendritic Cells Break Bonds to Tolerize

Slides:



Advertisements
Similar presentations
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Advertisements

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,
Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
Antigen-Primed CD8+ T Cells Call DCs for Back Up
Volume 31, Issue 2, Pages (August 2009)
The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response
Bridget A. Robinson, Timothy J. Nice  Immunity 
HIV-1 Latency by Transition
An Activation Marker Finds a Function
Independence Day for IgA
Erythropoietin Surprises: An Immune Saga
Memory: The Incomplete Unhappening of Differentiation
Toll-like Receptors Keep Antigen Sorting on the Right Track
Interleukin-22, the Guardian of the Intestinal Stem Cell Niche?
The Birds, the Bees, and Innate Immunity
Microbial Learning Lessons: SFB Educate the Immune System
The Lymphopenic Mouse in Immunology: From Patron to Pariah
Volume 29, Issue 5, Pages (November 2008)
Treg's Alter Ego: An Accessory in Tumor Killing
Taking T Cell Priming Down a Notch: Signaling through Notch Receptors Enhances T Cell Sensitivity to Antigen  Timothy J. Thauland, Manish J. Butte  Immunity 
Front-Line Memory T Cells Think Outside the T-box… Mostly
Loss of CD47 Makes Dendritic Cells See Red
Nicholas van Bruggen, Wenjun Ouyang  Immunity 
Chronic Infections Capture Little Attention of the Masses
Antigen to the Node: B Cells Go Native
A Flt3L Encounter: mTOR Signaling in Dendritic Cells
miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof
ILCs and T Cells Competing for Space: More Than a Numbers Game
T Helper 17 Cells Get the NOD
Double Duty for CCL21 in Dendritic Cell Trafficking
More Is Less: IL-9 in the Resolution of Inflammation
Neuropilin-1: The Glue between Regulatory T Cells and Dendritic Cells?
Mitchell Kronenberg, Yuki Kinjo  Immunity 
PU.1 Takes Control of the Dendritic Cell Lineage
Excitable T Cells: CaV1.4 Channel Contributions and Controversies
Intracellular Pathogens and CD8+ Dendritic Cells: Dangerous Liaisons
Arming Treg Cells at the Inflammatory Site
Fungi Take Control of Lymphocyte Recirculation
Fueling Memories Immunity Volume 36, Issue 1, Pages 3-5 (January 2012)
Volume 26, Issue 3, Pages (March 2007)
Chronic Infections Capture Little Attention of the Masses
Allergen Exposure: When Timing Is Everything
Erythropoietin Surprises: An Immune Saga
Allergen Exposure: When Timing Is Everything
BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens
Loss of CD47 Makes Dendritic Cells See Red
An IL-1β-Dependent Switch in Innate Mucosal Immunity?
Thomas S. Griffith, Thomas A. Ferguson  Immunity 
Maria A. Curotto de Lafaille, Juan J. Lafaille  Immunity 
Immunology of Food Allergy
Blood Tfh Cells Come with Colors
Volume 37, Issue 1, Pages 5-7 (July 2012)
HIV's Vagina Travelogue
Innate Lymphoid Cells in Inflammation and Immunity
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
A Prescription for Human Immunology
More Is Less: IL-9 in the Resolution of Inflammation
ILC-poiesis: Making Tissue ILCs from Blood
Double Duty for CCL21 in Dendritic Cell Trafficking
Volume 30, Issue 2, Pages (February 2009)
Cigarette Smoke Resets the Alarmin IL-33 in COPD
Professional Differences in Antigen Presentation to iNKT Cells
Regulatory T Cells: Context Matters
Sterile Inflammation Fuels Gastric Cancer
MicroRNA-155 Function in B Cells
Peripheral Tolerance of CD8 T Lymphocytes
Volume 35, Issue 6, Pages (December 2011)
IL-9 by INFERence Immunity
CTLA4Ig: Bridging the Basic Immunology with Clinical Application
Presentation transcript:

Dendritic Cells Break Bonds to Tolerize Maries van den Broek  Immunity  Volume 27, Issue 4, Pages 544-546 (October 2007) DOI: 10.1016/j.immuni.2007.10.004 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Induction of Tolerance by Cluster-Disrupted DCs DCs are attached to surrounding cells (gray cells) by E-cadherin. Disruption of these interactions results in a particular activation pathway of DC as described by Jiang et al. (2007). As a result, DCs upregulate costimulatory molecules and MHC and also CCR7, which allows migration into the T cell area of secondary lymphoid organs. The activation of DCs by loss of E-cadherin interactions, however, does not induce the production of cytokines. Upon arrival to the secondary lymphoid organ, these DCs tolerize naive T cells. Immunity 2007 27, 544-546DOI: (10.1016/j.immuni.2007.10.004) Copyright © 2007 Elsevier Inc. Terms and Conditions